IL-6/STAT3 Signaling Promotes Cardiac Dysfunction by Upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Formation in Sepsis Mice

AIMS: Cytokine storm is closely related to the initiation and progression of sepsis, and the level of IL-6 is positively correlated with mortality and organ dysfunction. Sepsis-induced myocardial dysfunction (SIMD) is one of the major complications. However, the role of the IL-6/STAT3 signaling in t...

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Detalles Bibliográficos
Autores principales: Jiang, Tao, Peng, Dewei, Shi, Wei, Guo, Junyi, Huo, Shengqi, Men, Lintong, Zhang, Cuntai, Li, Sheng, Lv, Jiagao, Lin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804492/
https://www.ncbi.nlm.nih.gov/pubmed/35118141
http://dx.doi.org/10.3389/fcvm.2021.790612

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