Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

Artificial glycan holes on recombinant Env-based vaccines occur when a potential N-linked glycosylation site (PNGS) is under-occupied, but not on their viral counterparts. Native-like SOSIP trimers, including clinical candidates, contain such holes in the glycan shield that induce strain-specific ne...

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Detalles Bibliográficos
Autores principales: Derking, Ronald, Allen, Joel D., Cottrell, Christopher A., Sliepen, Kwinten, Seabright, Gemma E., Lee, Wen-Hsin, Aldon, Yoann, Rantalainen, Kimmo, Antanasijevic, Aleksandar, Copps, Jeffrey, Yasmeen, Anila, Cupo, Albert, Portillo, Victor M. Cruz, Poniman, Meliawati, Bol, Niki, van der Woude, Patricia, de Taeye, Steven W., van den Kerkhof, Tom L.G.M., Klasse, P.J., Ozorowski, Gabriel, van Gils, Marit J., Moore, John P., Ward, Andrew B., Crispin, Max, Sanders, Rogier W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804554/
https://www.ncbi.nlm.nih.gov/pubmed/33826885
http://dx.doi.org/10.1016/j.celrep.2021.108933

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