RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells

RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of Rxra and Rxrb augments leukemic growth in mice. While defining the domains of RXRA that are required for anti-leukemic effects in murine KMT2A-MLLT3 leukemia cells, we unexpectedly identified RXRA DT448/9PP as a...

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Detalles Bibliográficos
Autores principales: di Martino, Orsola, Ferris, Margaret A., Hadwiger, Gayla, Sarkar, Soyi, Vu, Anh, Menéndez-Gutiérrez, María P., Ricote, Mercedes, Welch, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804561/
https://www.ncbi.nlm.nih.gov/pubmed/34134472
http://dx.doi.org/10.3324/haematol.2021.278603

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