Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia

Sickle cell disease (SCD) is an autosomal recessive genetic disease caused by a single point mutation, resulting in abnormal sickle hemoglobin (HbS). During hypoxia or dehydration, HbS polymerizes to form insoluble aggregates and induces sickling of red blood cells, which increases the adhesiveness...

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Detalles Bibliográficos
Autores principales: Abdulmalik, Osheiza, Darwish, Noureldien H. E., Muralidharan-Chari, Vandhana, Taleb, Maii Abu, Mousa, Shaker A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804574/
https://www.ncbi.nlm.nih.gov/pubmed/33567814
http://dx.doi.org/10.3324/haematol.2020.272393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804574/
https://www.ncbi.nlm.nih.gov/pubmed/33567814
http://dx.doi.org/10.3324/haematol.2020.272393

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