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Tumor mutation burden for predicting immune checkpoint blockade response: the more, the better

BACKGROUND: Recently, the US Food and Drug Administration (FDA) has approved immune checkpoint blockade (ICB) for treating cancer patients with tumor mutation burden (TMB) >10 mutations/megabase (mut/Mb). However, high TMB (TMB-H) defined by >10 mut/Mb fails to predict ICB response across diff...

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Detalles Bibliográficos
Autor principal:	Zheng, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804687/ https://www.ncbi.nlm.nih.gov/pubmed/35101940 http://dx.doi.org/10.1136/jitc-2021-003087

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