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Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics

Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics. The enzyme catalyses the Claisen condensation of malonyl-ACP (acyl carrier protein) with acyl-ACP via an acyl-enzyme intermediate. H...

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Detalles Bibliográficos
Autores principales:	Yadrykhins'ky, Vladyslav, Georgiou, Charis, Brenk, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804906/ https://www.ncbi.nlm.nih.gov/pubmed/35136566 http://dx.doi.org/10.12688/f1000research.74018.2

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