Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes

Polyubiquitination by E2 and E3 enzymes is crucial to cell cycle control, epigenetic regulation, and development. The hallmark of the E2 family is the ubiquitin (Ub)‐conjugating (UBC) domain that forms a dynamic thioester conjugate with ubiquitin (E2~Ub). Numerous studies have focused on E2 surfaces...

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Detalles Bibliográficos
Autores principales: Welsh, Kaeli A, Bolhuis, Derek L, Nederstigt, Anneroos E, Boyer, Joshua, Temple, Brenda R S, Bonacci, Thomas, Gu, Li, Ordureau, Alban, Harper, J Wade, Steimel, Joshua P, Zhang, Qi, Emanuele, Michael J, Harrison, Joseph S, Brown, Nicholas G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804933/
https://www.ncbi.nlm.nih.gov/pubmed/34942047
http://dx.doi.org/10.15252/embj.2021108823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804933/
https://www.ncbi.nlm.nih.gov/pubmed/34942047
http://dx.doi.org/10.15252/embj.2021108823

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