Cargando…
History of Suicide Attempts and COVID-19 Infection in Veterans with Schizophrenia or Schizoaffective Disorder: Moderating Effects of Age and Body Mass Index
INTRODUCTION: Relative to the general population, patients with schizophrenia or schizoaffective disorder have higher rates of suicide attempts and mortality from COVID-19 infection. Therefore, determining whether a history of suicide attempt is associated with COVID-19 in patients with schizophreni...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805065/ https://www.ncbi.nlm.nih.gov/pubmed/35128521 http://dx.doi.org/10.1159/000521230 |
_version_ | 1784643167814942720 |
---|---|
author | Okusaga, Olaoluwa O. Kember, Rachel L. Peloso, Gina M. Peterson, Roseann E. Vujkovic, Mariana Mitchell, Brian G. Bernard, Jared Walder, Annette Bigdeli, Tim B. |
author_facet | Okusaga, Olaoluwa O. Kember, Rachel L. Peloso, Gina M. Peterson, Roseann E. Vujkovic, Mariana Mitchell, Brian G. Bernard, Jared Walder, Annette Bigdeli, Tim B. |
author_sort | Okusaga, Olaoluwa O. |
collection | PubMed |
description | INTRODUCTION: Relative to the general population, patients with schizophrenia or schizoaffective disorder have higher rates of suicide attempts and mortality from COVID-19 infection. Therefore, determining whether a history of suicide attempt is associated with COVID-19 in patients with schizophrenia or schizoaffective disorder has implications for COVID-19 vulnerability stratification in this patient population. METHODS: We carried out cross-sectional analyses of electronic health records of veterans with a diagnosis of schizophrenia or schizoaffective disorder that received treatment at any United States Veterans Affairs Medical Center between January 1, 2020, and January 31, 2021. We used logistic regression to estimate unadjusted and adjusted (including age, sex, race, marital status, body mass index (BMI), and a medical comorbidity score) odds ratios (ORs) for COVID-19 positivity in suicide attempters relative to nonattempters. RESULTS: A total of 101,032 veterans (mean age 56.67 ± 13.13 years; males 91,715 [90.8%]) were included in the analyses. There were 2,703 (2.7%) suicide attempters and 719 (0.7%) patients were positive for COVID-19. The association between history of suicide attempt and COVID-19 positivity was modified by age and BMI, such that the relationship was only significant in patients younger than 59 years, and in obese (BMI ≥30) patients (adjusted OR 3.42, 95% CI 2.02–5.79 and OR 2.85, 95% CI 1.65–4.94, respectively). CONCLUSIONS: Higher rates of COVID-19 in young or obese suicide attempters with a diagnosis of schizophrenia or schizoaffective disorder might be due to the elevated risk for the infection in this subgroup of patients. |
format | Online Article Text |
id | pubmed-8805065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-88050652022-02-02 History of Suicide Attempts and COVID-19 Infection in Veterans with Schizophrenia or Schizoaffective Disorder: Moderating Effects of Age and Body Mass Index Okusaga, Olaoluwa O. Kember, Rachel L. Peloso, Gina M. Peterson, Roseann E. Vujkovic, Mariana Mitchell, Brian G. Bernard, Jared Walder, Annette Bigdeli, Tim B. Complex Psychiatry Research Article INTRODUCTION: Relative to the general population, patients with schizophrenia or schizoaffective disorder have higher rates of suicide attempts and mortality from COVID-19 infection. Therefore, determining whether a history of suicide attempt is associated with COVID-19 in patients with schizophrenia or schizoaffective disorder has implications for COVID-19 vulnerability stratification in this patient population. METHODS: We carried out cross-sectional analyses of electronic health records of veterans with a diagnosis of schizophrenia or schizoaffective disorder that received treatment at any United States Veterans Affairs Medical Center between January 1, 2020, and January 31, 2021. We used logistic regression to estimate unadjusted and adjusted (including age, sex, race, marital status, body mass index (BMI), and a medical comorbidity score) odds ratios (ORs) for COVID-19 positivity in suicide attempters relative to nonattempters. RESULTS: A total of 101,032 veterans (mean age 56.67 ± 13.13 years; males 91,715 [90.8%]) were included in the analyses. There were 2,703 (2.7%) suicide attempters and 719 (0.7%) patients were positive for COVID-19. The association between history of suicide attempt and COVID-19 positivity was modified by age and BMI, such that the relationship was only significant in patients younger than 59 years, and in obese (BMI ≥30) patients (adjusted OR 3.42, 95% CI 2.02–5.79 and OR 2.85, 95% CI 1.65–4.94, respectively). CONCLUSIONS: Higher rates of COVID-19 in young or obese suicide attempters with a diagnosis of schizophrenia or schizoaffective disorder might be due to the elevated risk for the infection in this subgroup of patients. S. Karger AG 2022-09 2021-12-01 /pmc/articles/PMC8805065/ /pubmed/35128521 http://dx.doi.org/10.1159/000521230 Text en Copyright © 2021 by S. Karger AG, Basel https://www.karger.com/Services/SiteLicensesCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. |
spellingShingle | Research Article Okusaga, Olaoluwa O. Kember, Rachel L. Peloso, Gina M. Peterson, Roseann E. Vujkovic, Mariana Mitchell, Brian G. Bernard, Jared Walder, Annette Bigdeli, Tim B. History of Suicide Attempts and COVID-19 Infection in Veterans with Schizophrenia or Schizoaffective Disorder: Moderating Effects of Age and Body Mass Index |
title | History of Suicide Attempts and COVID-19 Infection in Veterans with Schizophrenia or Schizoaffective Disorder: Moderating Effects of Age and Body Mass Index |
title_full | History of Suicide Attempts and COVID-19 Infection in Veterans with Schizophrenia or Schizoaffective Disorder: Moderating Effects of Age and Body Mass Index |
title_fullStr | History of Suicide Attempts and COVID-19 Infection in Veterans with Schizophrenia or Schizoaffective Disorder: Moderating Effects of Age and Body Mass Index |
title_full_unstemmed | History of Suicide Attempts and COVID-19 Infection in Veterans with Schizophrenia or Schizoaffective Disorder: Moderating Effects of Age and Body Mass Index |
title_short | History of Suicide Attempts and COVID-19 Infection in Veterans with Schizophrenia or Schizoaffective Disorder: Moderating Effects of Age and Body Mass Index |
title_sort | history of suicide attempts and covid-19 infection in veterans with schizophrenia or schizoaffective disorder: moderating effects of age and body mass index |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805065/ https://www.ncbi.nlm.nih.gov/pubmed/35128521 http://dx.doi.org/10.1159/000521230 |
work_keys_str_mv | AT okusagaolaoluwao historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex AT kemberrachell historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex AT pelosoginam historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex AT petersonroseanne historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex AT vujkovicmariana historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex AT mitchellbriang historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex AT bernardjared historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex AT walderannette historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex AT bigdelitimb historyofsuicideattemptsandcovid19infectioninveteranswithschizophreniaorschizoaffectivedisordermoderatingeffectsofageandbodymassindex |