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SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait
OBJECTIVES: We aimed to describe the clinical characteristics of SARS-CoV-2 infection and estimate viral shedding duration in respiratory specimens. METHODS: A retrospective cohort study was performed from February 25 to March 25, 2020. In Kuwait, all suspected coronavirus disease 2019 (COVID-19) ca...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805077/ https://www.ncbi.nlm.nih.gov/pubmed/34883487 http://dx.doi.org/10.1159/000521408 |
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author | Alghounaim, Mohammad Caya, Chelsea Alothman, Khalid Alhasawi, Almonther Papenburg, Jesse |
author_facet | Alghounaim, Mohammad Caya, Chelsea Alothman, Khalid Alhasawi, Almonther Papenburg, Jesse |
author_sort | Alghounaim, Mohammad |
collection | PubMed |
description | OBJECTIVES: We aimed to describe the clinical characteristics of SARS-CoV-2 infection and estimate viral shedding duration in respiratory specimens. METHODS: A retrospective cohort study was performed from February 25 to March 25, 2020. In Kuwait, all suspected coronavirus disease 2019 (COVID-19) cases, contacts of cases, and returning travelers were systematically tested for SARS-CoV-2 by RT-PCR. All infected persons, regardless of symptoms, were hospitalized and serially tested until they had two negative results. Descriptive statistics and regression analyses were performed. RESULTS: Two hundred seven cases of SARS-CoV-2 infection were included in this study. About half of the cases were asymptomatic and 1.9% died. The median time to negative RT-PCR was 22 days. Increasing age, ARDS, and low peripheral white blood cell count were associated with prolonged PCR positivity. CONCLUSION: Predictors for prolonged RT-PCR positivity included increasing age, ARDS, and low white blood cell count. The findings of this study may aid in better understanding of the epidemiology of SARS-CoV-2 infection and molecular testing dynamics. |
format | Online Article Text |
id | pubmed-8805077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-88050772022-02-02 SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait Alghounaim, Mohammad Caya, Chelsea Alothman, Khalid Alhasawi, Almonther Papenburg, Jesse Med Princ Pract Brief Report OBJECTIVES: We aimed to describe the clinical characteristics of SARS-CoV-2 infection and estimate viral shedding duration in respiratory specimens. METHODS: A retrospective cohort study was performed from February 25 to March 25, 2020. In Kuwait, all suspected coronavirus disease 2019 (COVID-19) cases, contacts of cases, and returning travelers were systematically tested for SARS-CoV-2 by RT-PCR. All infected persons, regardless of symptoms, were hospitalized and serially tested until they had two negative results. Descriptive statistics and regression analyses were performed. RESULTS: Two hundred seven cases of SARS-CoV-2 infection were included in this study. About half of the cases were asymptomatic and 1.9% died. The median time to negative RT-PCR was 22 days. Increasing age, ARDS, and low peripheral white blood cell count were associated with prolonged PCR positivity. CONCLUSION: Predictors for prolonged RT-PCR positivity included increasing age, ARDS, and low white blood cell count. The findings of this study may aid in better understanding of the epidemiology of SARS-CoV-2 infection and molecular testing dynamics. S. Karger AG 2021-12-09 /pmc/articles/PMC8805077/ /pubmed/34883487 http://dx.doi.org/10.1159/000521408 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. |
spellingShingle | Brief Report Alghounaim, Mohammad Caya, Chelsea Alothman, Khalid Alhasawi, Almonther Papenburg, Jesse SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait |
title | SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait |
title_full | SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait |
title_fullStr | SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait |
title_full_unstemmed | SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait |
title_short | SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait |
title_sort | sars-cov-2 clinical characteristics and viral shedding in kuwait |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805077/ https://www.ncbi.nlm.nih.gov/pubmed/34883487 http://dx.doi.org/10.1159/000521408 |
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