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Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019

BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is currently the most important etiological agent of acute respiratory distress syndrome (ARDS) with millions of infections and deaths in the last 2 years worldwide. Several reasons and parameters are responsible for the diffic...

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Autores principales: Fallah, Ali, Razavi Nikoo, Hadi, Abbasi, Hamidreza, Mohammad-Hasani, Azadeh, Hosseinzadeh Colagar, Abasalt, Khosravi, Ayyoob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805078/
https://www.ncbi.nlm.nih.gov/pubmed/34666335
http://dx.doi.org/10.1159/000520234
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author Fallah, Ali
Razavi Nikoo, Hadi
Abbasi, Hamidreza
Mohammad-Hasani, Azadeh
Hosseinzadeh Colagar, Abasalt
Khosravi, Ayyoob
author_facet Fallah, Ali
Razavi Nikoo, Hadi
Abbasi, Hamidreza
Mohammad-Hasani, Azadeh
Hosseinzadeh Colagar, Abasalt
Khosravi, Ayyoob
author_sort Fallah, Ali
collection PubMed
description BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is currently the most important etiological agent of acute respiratory distress syndrome (ARDS) with millions of infections and deaths in the last 2 years worldwide. Several reasons and parameters are responsible for the difficult management of coronavirus disease-2019 (COVID-19) patients; the first is virus behavioral factors such as high transmission rate, and the different molecular and cellular mechanisms of pathogenesis remain a matter of controversy, which is another factor. SUMMARY: In the present review, we attempted to explain about features of SARS-COV-2, particularly focusing on the various aspects of pathogenesis and treatment strategies. KEY MESSAGES: We note evidence for the understanding of the precise molecular and cellular mechanisms of SARS-CoV-2 pathogenesis, which can help design the appropriate drug or vaccine. Additionally, and importantly, we reported the updated issues associated with the history and development of treatment strategies such as, drugs, vaccines, and other medications that have been approved or under consideration in clinics and markets worldwide.
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spelling pubmed-88050782022-02-02 Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019 Fallah, Ali Razavi Nikoo, Hadi Abbasi, Hamidreza Mohammad-Hasani, Azadeh Hosseinzadeh Colagar, Abasalt Khosravi, Ayyoob Intervirology Review Article BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is currently the most important etiological agent of acute respiratory distress syndrome (ARDS) with millions of infections and deaths in the last 2 years worldwide. Several reasons and parameters are responsible for the difficult management of coronavirus disease-2019 (COVID-19) patients; the first is virus behavioral factors such as high transmission rate, and the different molecular and cellular mechanisms of pathogenesis remain a matter of controversy, which is another factor. SUMMARY: In the present review, we attempted to explain about features of SARS-COV-2, particularly focusing on the various aspects of pathogenesis and treatment strategies. KEY MESSAGES: We note evidence for the understanding of the precise molecular and cellular mechanisms of SARS-CoV-2 pathogenesis, which can help design the appropriate drug or vaccine. Additionally, and importantly, we reported the updated issues associated with the history and development of treatment strategies such as, drugs, vaccines, and other medications that have been approved or under consideration in clinics and markets worldwide. S. Karger AG 2021-10-25 /pmc/articles/PMC8805078/ /pubmed/34666335 http://dx.doi.org/10.1159/000520234 Text en Copyright © 2021 by The Author(s) Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
spellingShingle Review Article
Fallah, Ali
Razavi Nikoo, Hadi
Abbasi, Hamidreza
Mohammad-Hasani, Azadeh
Hosseinzadeh Colagar, Abasalt
Khosravi, Ayyoob
Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019
title Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019
title_full Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019
title_fullStr Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019
title_full_unstemmed Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019
title_short Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019
title_sort features of pathobiology and clinical translation of approved treatments for coronavirus disease 2019
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805078/
https://www.ncbi.nlm.nih.gov/pubmed/34666335
http://dx.doi.org/10.1159/000520234
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