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Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function

Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturatio...

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Detalles Bibliográficos
Autores principales: Valdivia, Anddre Osmar, Bhattacharya, Sanjoy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805197/
https://www.ncbi.nlm.nih.gov/pubmed/35027445
http://dx.doi.org/10.1523/ENEURO.0429-21.2022
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author Valdivia, Anddre Osmar
Bhattacharya, Sanjoy K.
author_facet Valdivia, Anddre Osmar
Bhattacharya, Sanjoy K.
author_sort Valdivia, Anddre Osmar
collection PubMed
description Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our in vitro studies show LPC 18:1 protection against neuron-ectopic hyperdeimination and stimulation of oligodendrocyte maturation, while in vivo investigations recorded optic nerve function improvement following optic nerve injections of LPC 18:1, in contrast with LPC 18:0. Thus, just a change in a single bond renders a dramatic alternation in biological function. The incorporation of isobaric C13-histidine in newly synthesized myelin proteins and quantitative proteome shifts are consistent with remyelination underlying restoration in optic nerve function. These results suggest that exogenous LPC 18:1 may provide a therapeutic avenue for stemming vision loss in demyelinating diseases.
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spelling pubmed-88051972022-02-01 Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function Valdivia, Anddre Osmar Bhattacharya, Sanjoy K. eNeuro Research Article: New Research Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our in vitro studies show LPC 18:1 protection against neuron-ectopic hyperdeimination and stimulation of oligodendrocyte maturation, while in vivo investigations recorded optic nerve function improvement following optic nerve injections of LPC 18:1, in contrast with LPC 18:0. Thus, just a change in a single bond renders a dramatic alternation in biological function. The incorporation of isobaric C13-histidine in newly synthesized myelin proteins and quantitative proteome shifts are consistent with remyelination underlying restoration in optic nerve function. These results suggest that exogenous LPC 18:1 may provide a therapeutic avenue for stemming vision loss in demyelinating diseases. Society for Neuroscience 2022-01-24 /pmc/articles/PMC8805197/ /pubmed/35027445 http://dx.doi.org/10.1523/ENEURO.0429-21.2022 Text en Copyright © 2022 Valdivia and Bhattacharya https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Valdivia, Anddre Osmar
Bhattacharya, Sanjoy K.
Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function
title Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function
title_full Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function
title_fullStr Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function
title_full_unstemmed Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function
title_short Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function
title_sort lyso-lipid-induced oligodendrocyte maturation underlies restoration of optic nerve function
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805197/
https://www.ncbi.nlm.nih.gov/pubmed/35027445
http://dx.doi.org/10.1523/ENEURO.0429-21.2022
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