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Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function
Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturatio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805197/ https://www.ncbi.nlm.nih.gov/pubmed/35027445 http://dx.doi.org/10.1523/ENEURO.0429-21.2022 |
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author | Valdivia, Anddre Osmar Bhattacharya, Sanjoy K. |
author_facet | Valdivia, Anddre Osmar Bhattacharya, Sanjoy K. |
author_sort | Valdivia, Anddre Osmar |
collection | PubMed |
description | Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our in vitro studies show LPC 18:1 protection against neuron-ectopic hyperdeimination and stimulation of oligodendrocyte maturation, while in vivo investigations recorded optic nerve function improvement following optic nerve injections of LPC 18:1, in contrast with LPC 18:0. Thus, just a change in a single bond renders a dramatic alternation in biological function. The incorporation of isobaric C13-histidine in newly synthesized myelin proteins and quantitative proteome shifts are consistent with remyelination underlying restoration in optic nerve function. These results suggest that exogenous LPC 18:1 may provide a therapeutic avenue for stemming vision loss in demyelinating diseases. |
format | Online Article Text |
id | pubmed-8805197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-88051972022-02-01 Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function Valdivia, Anddre Osmar Bhattacharya, Sanjoy K. eNeuro Research Article: New Research Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our in vitro studies show LPC 18:1 protection against neuron-ectopic hyperdeimination and stimulation of oligodendrocyte maturation, while in vivo investigations recorded optic nerve function improvement following optic nerve injections of LPC 18:1, in contrast with LPC 18:0. Thus, just a change in a single bond renders a dramatic alternation in biological function. The incorporation of isobaric C13-histidine in newly synthesized myelin proteins and quantitative proteome shifts are consistent with remyelination underlying restoration in optic nerve function. These results suggest that exogenous LPC 18:1 may provide a therapeutic avenue for stemming vision loss in demyelinating diseases. Society for Neuroscience 2022-01-24 /pmc/articles/PMC8805197/ /pubmed/35027445 http://dx.doi.org/10.1523/ENEURO.0429-21.2022 Text en Copyright © 2022 Valdivia and Bhattacharya https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article: New Research Valdivia, Anddre Osmar Bhattacharya, Sanjoy K. Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function |
title | Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function |
title_full | Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function |
title_fullStr | Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function |
title_full_unstemmed | Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function |
title_short | Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function |
title_sort | lyso-lipid-induced oligodendrocyte maturation underlies restoration of optic nerve function |
topic | Research Article: New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805197/ https://www.ncbi.nlm.nih.gov/pubmed/35027445 http://dx.doi.org/10.1523/ENEURO.0429-21.2022 |
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