A novel prostaglandin I(2) agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice

BACKGROUND: ONO-1301 is a novel long-lasting prostaglandin (PG) I(2) mimetic with inhibitory activity on thromboxane (TX) A(2) synthase. This drug can also induce endogenous prostaglandin (PG)I2 and PGE2 levels. Furthermore, ONO-1301 acts as a cytokine inducer and can initiate tissue repair in a var...

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Detalles Bibliográficos
Autores principales: Motegi, Satoko, Tsuchiya, Atsunori, Iwasawa, Takahiro, Sato, Takeki, Kumagai, Masaru, Natsui, Kazuki, Nojiri, Shunsuke, Ogawa, Masahiro, Takeuchi, Suguru, Sakai, Yosiki, Miyagawa, Shigeru, Sawa, Yoshiki, Terai, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805395/
https://www.ncbi.nlm.nih.gov/pubmed/35101153
http://dx.doi.org/10.1186/s41232-021-00191-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805395/
https://www.ncbi.nlm.nih.gov/pubmed/35101153
http://dx.doi.org/10.1186/s41232-021-00191-6

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