Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

BACKGROUND: Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset neurodegeneration, neuroinflammation, demyelinati...

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Detalles Bibliográficos
Autores principales: Dodge, James C., Tamsett, Thomas J., Treleaven, Christopher M., Taksir, Tatyana V., Piepenhagen, Peter, Sardi, S. Pablo, Cheng, Seng H., Shihabuddin, Lamya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805417/
https://www.ncbi.nlm.nih.gov/pubmed/35105352
http://dx.doi.org/10.1186/s13195-022-00966-0

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