4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing

4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administratio...

Descripción completa

Detalles Bibliográficos
Autor principal: Kim, Seong-Gon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805429/
https://www.ncbi.nlm.nih.gov/pubmed/35103875
http://dx.doi.org/10.1186/s40902-022-00334-w
_version_ 1784643250292785152
author Kim, Seong-Gon
author_facet Kim, Seong-Gon
author_sort Kim, Seong-Gon
collection PubMed
description 4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administration increases VEGF, TGF-β1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound.
format Online
Article
Text
id pubmed-8805429
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Singapore
record_format MEDLINE/PubMed
spelling pubmed-88054292022-02-01 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing Kim, Seong-Gon Maxillofac Plast Reconstr Surg Review 4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administration increases VEGF, TGF-β1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound. Springer Singapore 2022-02-01 /pmc/articles/PMC8805429/ /pubmed/35103875 http://dx.doi.org/10.1186/s40902-022-00334-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kim, Seong-Gon
4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
title 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
title_full 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
title_fullStr 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
title_full_unstemmed 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
title_short 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
title_sort 4-hexylresorcinol: pharmacologic chaperone and its application for wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805429/
https://www.ncbi.nlm.nih.gov/pubmed/35103875
http://dx.doi.org/10.1186/s40902-022-00334-w
work_keys_str_mv AT kimseonggon 4hexylresorcinolpharmacologicchaperoneanditsapplicationforwoundhealing

Ejemplares similares