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Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection

Purpose: To investigate the effect of syphilis infection on the microstructure of white matter (WM) in HIV-infected male patients using diffusion tensor imaging (DTI). Methods: Twenty-seven HIV-infected male patients with current syphilis or a history of syphilis (HIV +/syphilis +), twenty-nine HIV-...

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Autores principales: Qi, Yu, Li, Rui-Li, Wang, Yuan-Yuan, Wang, Wei, Liu, Xu-Ze, Liu, Jing, Li, Xing, Zhang, Xiao-Dong, Yu, Wen, Liu, Jiao-Jiao, Guo, Yi-Fan, Rao, Bo, Li, Hong-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805514/
https://www.ncbi.nlm.nih.gov/pubmed/35115993
http://dx.doi.org/10.3389/fneur.2021.776818
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author Qi, Yu
Li, Rui-Li
Wang, Yuan-Yuan
Wang, Wei
Liu, Xu-Ze
Liu, Jing
Li, Xing
Zhang, Xiao-Dong
Yu, Wen
Liu, Jiao-Jiao
Guo, Yi-Fan
Rao, Bo
Li, Hong-Jun
author_facet Qi, Yu
Li, Rui-Li
Wang, Yuan-Yuan
Wang, Wei
Liu, Xu-Ze
Liu, Jing
Li, Xing
Zhang, Xiao-Dong
Yu, Wen
Liu, Jiao-Jiao
Guo, Yi-Fan
Rao, Bo
Li, Hong-Jun
author_sort Qi, Yu
collection PubMed
description Purpose: To investigate the effect of syphilis infection on the microstructure of white matter (WM) in HIV-infected male patients using diffusion tensor imaging (DTI). Methods: Twenty-seven HIV-infected male patients with current syphilis or a history of syphilis (HIV +/syphilis +), twenty-nine HIV-infected male patients without syphilis co-infection (HIV +/syphilis–), and twenty-nine healthy controls (HC) were enrolled. All participants received DTI, and all patients received comprehensive neuropsychological assessment. Tract-based spatial statistics (TBSS) was adopted to analyze the DTI measures: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). Correlation analysis was conducted to investigate the relationships between DTI measures and cognitive performance. Results: There were no significant differences in DTI measures between HIV+/syphilis– and HC. Compared with HC, lower FA was found in body of corpus callosum (BCC), splenium of corpus callosum (SCC), genu of corpus callosum (GCC), the bilateral anterior corona radiata (ACR), superior corona radiata (SCR), posterior corona radiata (PCR), and posterior thalamic radiation (PTR) in HIV+/syphilis+ (p < 0.05). Higher RD was found in BCC and SCC (p < 0.05). Compared with HIV+/syphilis–, lower scores were found in complex motor skills (CMS) in HIV+/syphilis+, lower FA was found in BCC, SCC, GCC, the bilateral ACR, SCR, PCR, PTR, cingulate gyrus (CGC), the right inferior fronto-occipital fasciculus (IFO), the retrolenticular part of internal capsule (RLIC), sagittal stratum (SS), external capsule (EC) in HIV+/syphilis+ (p < 0.01). Correlation analysis uncorrected for multiple comparisons showed there was a positive correlation between FA in GCC and CMS, FA in BCC, and CMS in HIV+/syphilis+. Conclusions: Syphilis co-infection can have an additive or synergistic effect on the brain WM in HIV-infected subjects. HIV-infected patients without syphilis should be actively treated to avoid syphilis infection.
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spelling pubmed-88055142022-02-02 Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection Qi, Yu Li, Rui-Li Wang, Yuan-Yuan Wang, Wei Liu, Xu-Ze Liu, Jing Li, Xing Zhang, Xiao-Dong Yu, Wen Liu, Jiao-Jiao Guo, Yi-Fan Rao, Bo Li, Hong-Jun Front Neurol Neurology Purpose: To investigate the effect of syphilis infection on the microstructure of white matter (WM) in HIV-infected male patients using diffusion tensor imaging (DTI). Methods: Twenty-seven HIV-infected male patients with current syphilis or a history of syphilis (HIV +/syphilis +), twenty-nine HIV-infected male patients without syphilis co-infection (HIV +/syphilis–), and twenty-nine healthy controls (HC) were enrolled. All participants received DTI, and all patients received comprehensive neuropsychological assessment. Tract-based spatial statistics (TBSS) was adopted to analyze the DTI measures: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). Correlation analysis was conducted to investigate the relationships between DTI measures and cognitive performance. Results: There were no significant differences in DTI measures between HIV+/syphilis– and HC. Compared with HC, lower FA was found in body of corpus callosum (BCC), splenium of corpus callosum (SCC), genu of corpus callosum (GCC), the bilateral anterior corona radiata (ACR), superior corona radiata (SCR), posterior corona radiata (PCR), and posterior thalamic radiation (PTR) in HIV+/syphilis+ (p < 0.05). Higher RD was found in BCC and SCC (p < 0.05). Compared with HIV+/syphilis–, lower scores were found in complex motor skills (CMS) in HIV+/syphilis+, lower FA was found in BCC, SCC, GCC, the bilateral ACR, SCR, PCR, PTR, cingulate gyrus (CGC), the right inferior fronto-occipital fasciculus (IFO), the retrolenticular part of internal capsule (RLIC), sagittal stratum (SS), external capsule (EC) in HIV+/syphilis+ (p < 0.01). Correlation analysis uncorrected for multiple comparisons showed there was a positive correlation between FA in GCC and CMS, FA in BCC, and CMS in HIV+/syphilis+. Conclusions: Syphilis co-infection can have an additive or synergistic effect on the brain WM in HIV-infected subjects. HIV-infected patients without syphilis should be actively treated to avoid syphilis infection. Frontiers Media S.A. 2022-01-18 /pmc/articles/PMC8805514/ /pubmed/35115993 http://dx.doi.org/10.3389/fneur.2021.776818 Text en Copyright © 2022 Qi, Li, Wang, Wang, Liu, Liu, Li, Zhang, Yu, Liu, Guo, Rao and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Qi, Yu
Li, Rui-Li
Wang, Yuan-Yuan
Wang, Wei
Liu, Xu-Ze
Liu, Jing
Li, Xing
Zhang, Xiao-Dong
Yu, Wen
Liu, Jiao-Jiao
Guo, Yi-Fan
Rao, Bo
Li, Hong-Jun
Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection
title Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection
title_full Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection
title_fullStr Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection
title_full_unstemmed Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection
title_short Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection
title_sort characteristics of brain white matter microstructure in hiv male patients with primary syphilis co-infection
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805514/
https://www.ncbi.nlm.nih.gov/pubmed/35115993
http://dx.doi.org/10.3389/fneur.2021.776818
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