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Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria

Superbugs are bacteria that have grown resistant to most antibiotics, seriously threating the health of people. Silver (Ag) nanoparticles are known to exert a wide‐spectrum antimicrobial property, yet remains challenging against superbugs. Here, Ag clusters are assembled using porphyrin‐based linker...

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Autores principales: Cao, Man, Wang, Shan, Hu, Jia‐Hua, Lu, Bing‐Huai, Wang, Qian‐You, Zang, Shuang‐Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805555/
https://www.ncbi.nlm.nih.gov/pubmed/34761563
http://dx.doi.org/10.1002/advs.202103721
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author Cao, Man
Wang, Shan
Hu, Jia‐Hua
Lu, Bing‐Huai
Wang, Qian‐You
Zang, Shuang‐Quan
author_facet Cao, Man
Wang, Shan
Hu, Jia‐Hua
Lu, Bing‐Huai
Wang, Qian‐You
Zang, Shuang‐Quan
author_sort Cao, Man
collection PubMed
description Superbugs are bacteria that have grown resistant to most antibiotics, seriously threating the health of people. Silver (Ag) nanoparticles are known to exert a wide‐spectrum antimicrobial property, yet remains challenging against superbugs. Here, Ag clusters are assembled using porphyrin‐based linkers and a novel framework structure (Ag(9)‐AgTPyP) is produced, in which nine‐nuclearity Ag(9) clusters are uniformly separated by Ag‐centered porphyrin units (AgTPyP) in two dimensions, demonstrating open permeant porosity. Ag(9)‐AgTPyP eliminates over 99.99999% and 99.999% methicillin‐resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) within 2 h upon visible‐light irradiation, which are superior to a majority of bacteria inactivation photocatalysts. The novel‐established long‐term charge‐transfer states from AgTPyP to adjacent Ag(9) cluster that has preferential affinity to O(2) greatly promote reactive oxygen species (ROS) production efficiency; and its unique framework accelerates the ROS transportation. Personal protective equipment (masks and protective suits) incorporating Ag(9)‐AgTPyP film also shows excellent performances against superbugs. This superbugs‐killing efficiency is unprecedented among silver complexes and porphyrin derivatives. Utilizing efficient photogenerated electrons and holes between metal cluster and linkers can open up new interests of research in photocatalytic areas.
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spelling pubmed-88055552022-02-04 Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria Cao, Man Wang, Shan Hu, Jia‐Hua Lu, Bing‐Huai Wang, Qian‐You Zang, Shuang‐Quan Adv Sci (Weinh) Research Articles Superbugs are bacteria that have grown resistant to most antibiotics, seriously threating the health of people. Silver (Ag) nanoparticles are known to exert a wide‐spectrum antimicrobial property, yet remains challenging against superbugs. Here, Ag clusters are assembled using porphyrin‐based linkers and a novel framework structure (Ag(9)‐AgTPyP) is produced, in which nine‐nuclearity Ag(9) clusters are uniformly separated by Ag‐centered porphyrin units (AgTPyP) in two dimensions, demonstrating open permeant porosity. Ag(9)‐AgTPyP eliminates over 99.99999% and 99.999% methicillin‐resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) within 2 h upon visible‐light irradiation, which are superior to a majority of bacteria inactivation photocatalysts. The novel‐established long‐term charge‐transfer states from AgTPyP to adjacent Ag(9) cluster that has preferential affinity to O(2) greatly promote reactive oxygen species (ROS) production efficiency; and its unique framework accelerates the ROS transportation. Personal protective equipment (masks and protective suits) incorporating Ag(9)‐AgTPyP film also shows excellent performances against superbugs. This superbugs‐killing efficiency is unprecedented among silver complexes and porphyrin derivatives. Utilizing efficient photogenerated electrons and holes between metal cluster and linkers can open up new interests of research in photocatalytic areas. John Wiley and Sons Inc. 2021-11-10 /pmc/articles/PMC8805555/ /pubmed/34761563 http://dx.doi.org/10.1002/advs.202103721 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Cao, Man
Wang, Shan
Hu, Jia‐Hua
Lu, Bing‐Huai
Wang, Qian‐You
Zang, Shuang‐Quan
Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria
title Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria
title_full Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria
title_fullStr Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria
title_full_unstemmed Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria
title_short Silver Cluster‐Porphyrin‐Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria
title_sort silver cluster‐porphyrin‐assembled materials as advanced bioprotective materials for combating superbacteria
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805555/
https://www.ncbi.nlm.nih.gov/pubmed/34761563
http://dx.doi.org/10.1002/advs.202103721
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