Cargando…

Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy

Cardiac hypertrophy is a pivotal pathophysiological step of various cardiovascular diseases, which eventually leads to heart failure and death. Extracts of Rhodiola species (Ext.R), a class of commonly used medicinal herbs in Europe and East Asia, can attenuate cardiac hypertrophy both in vitro and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Shujing, Wang, Yingchao, Yu, Min, Shang, Ye, Chang, Yanxu, Zhao, Hong, Kang, Yu, Zhao, Lu, Xu, Lei, Zhao, Xiaoping, Difrancesco, Dario, Baruscotti, Mirko, Wang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805583/ https://www.ncbi.nlm.nih.gov/pubmed/34761560 http://dx.doi.org/10.1002/advs.202101485

Ejemplares similares

Rhodiosin and herbacetin in Rhodiola rosea preparations: additional markers for quality control?
por: Péter Zomborszki, Zoltán, et al.
Publicado: (2019)

Current-dependent Block of Rabbit Sino-Atrial Node I(f) Channels by Ivabradine
por: Bucchi, Annalisa, et al.
Publicado: (2002)

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models
por: Bucchi, Annalisa, et al.
Publicado: (2012)

Integrated Allosteric Model of Voltage Gating of Hcn Channels
por: Altomare, Claudia, et al.
Publicado: (2001)

Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels
por: Bucchi, Annalisa, et al.
Publicado: (2013)

Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice
por: Piantoni, Chiara, et al.
Publicado: (2021)

GPR30 Alleviates Pressure Overload-Induced Myocardial Hypertrophy in Ovariectomized Mice by Regulating Autophagy
por: Zhang, Shuaishuai, et al.
Publicado: (2023)

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader
por: Tovell, Hannah, et al.
Publicado: (2019)

Microwave-Assisted Extraction of Herbacetin Diglucoside from Flax (Linum usitatissimum L.) Seed Cakes and Its Quantification using an RP-HPLC-UV System
por: Fliniaux, Ophélie, et al.
Publicado: (2014)

Screening and Identification of Cardioprotective Compounds From Wenxin Keli by Activity Index Approach and in vivo Zebrafish Model
por: Liu, Hao, et al.
Publicado: (2018)

An Integrated Strategy of Chemical Fingerprint and Network Pharmacology for the Discovery of Efficacy-Related Q-Markers of Pheretima
por: Shang, Ye, et al.
Publicado: (2022)

Contributions of SGK3 to transporter-related diseases
por: Liao, Qian-Qian, et al.
Publicado: (2022)

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
por: Sommer, Eeva M., et al.
Publicado: (2013)

Does Transient Receptor Potential Vanilloid Type 1 Alleviate or Aggravate Pathological Myocardial Hypertrophy?
por: Yan, Qiqi, et al.
Publicado: (2021)

Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels
por: Piantoni, Chiara, et al.
Publicado: (2022)

Therapeutic inhibition of SGK1 suppresses colorectal cancer
por: Liang, Xuchun, et al.
Publicado: (2017)

Scoparone alleviates Ang II‐induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress
por: Lyu, Linmao, et al.
Publicado: (2021)

SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation
por: Xi, Xin, et al.
Publicado: (2019)

Identification of the natural chalcone glycoside hydroxysafflor yellow A as a suppressor of P53 overactivation‐associated hematopoietic defects
por: Chen, Jing, et al.
Publicado: (2023)

Editorial: Dissecting Traditional Medicine via Chemical and Biochemical Techniques: Advanced Analytics and Novel Paradigms
por: Wang, Yi, et al.
Publicado: (2022)

p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis
por: Li, Bo, et al.
Publicado: (2019)

JNK, p38, ERK, and SGK1 Inhibitors in Cancer
por: Cicenas, Jonas, et al.
Publicado: (2017)

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth
por: Bago, Ruzica, et al.
Publicado: (2016)

Aldosterone, SGK1, and ion channels in the kidney
por: Valinsky, William C., et al.
Publicado: (2018)

The functional duality of SGK1 in the regulation of hyperglycemia
por: Yang, Chunliang, et al.
Publicado: (2020)

SGK1 in Cancer: Biomarker and Drug Target
por: Cicenas, Jonas, et al.
Publicado: (2022)

Xin-Ji-Er-Kang Alleviates Isoproterenol-Induced Myocardial Hypertrophy in Mice through the Nrf2/HO-1 Signaling Pathway
por: Yu, Ting-Ting, et al.
Publicado: (2022)

YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy
por: Xu, Hongfei, et al.
Publicado: (2021)

Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPARγ/SGK1 signaling pathway
por: He, Jing, et al.
Publicado: (2019)

HDAC2 interacts with microRNA-503-5p to regulate SGK1 in osteoarthritis
por: Wang, Zheng, et al.
Publicado: (2021)

TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF-7 cells
por: Zhao, Shuai, et al.
Publicado: (2020)

SGK1 Inhibits Autophagy in Murine Muscle Tissue
por: Zuleger, Theresia, et al.
Publicado: (2018)

SGK1 in Human Cancer: Emerging Roles and Mechanisms
por: Sang, Yiwen, et al.
Publicado: (2021)

Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer
por: Wang, Min, et al.
Publicado: (2019)

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction
por: Milanesi, Raffaella, et al.
Publicado: (2015)

Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway
por: Wang, Longbin, et al.
Publicado: (2023)

SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT
por: Liu, Weiwei, et al.
Publicado: (2018)

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury
por: Wang, Lijun, et al.
Publicado: (2022)

Lack of PPARβ/δ-Inactivated SGK-1 Is Implicated in Liver Carcinogenesis
por: Shen, Bo, et al.
Publicado: (2020)

Celecoxib alleviates pathological cardiac hypertrophy and fibrosis via M1-like macrophage infiltration in neonatal mice
por: Zhao, Yanli, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hpomav8h8f31anbj5ebv4l1b1m