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Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia

Catatonia is a psychomotor syndrome common to several medical and neuropsychiatric disorders. Here, we report on the case of a 95-year-old woman who underwent a radical change in personality characterized by sexual disinhibition, and physical and verbal aggressiveness. Over several months, she devel...

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Autores principales: de França, Gustavo Campos, Barreto, Henrique Carneiro de Barros, Paranhos, Thiago, Nunes, Julio Cesar, de Oliveira-Souza, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805594/
https://www.ncbi.nlm.nih.gov/pubmed/35115996
http://dx.doi.org/10.3389/fneur.2021.798264
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author de França, Gustavo Campos
Barreto, Henrique Carneiro de Barros
Paranhos, Thiago
Nunes, Julio Cesar
de Oliveira-Souza, Ricardo
author_facet de França, Gustavo Campos
Barreto, Henrique Carneiro de Barros
Paranhos, Thiago
Nunes, Julio Cesar
de Oliveira-Souza, Ricardo
author_sort de França, Gustavo Campos
collection PubMed
description Catatonia is a psychomotor syndrome common to several medical and neuropsychiatric disorders. Here, we report on the case of a 95-year-old woman who underwent a radical change in personality characterized by sexual disinhibition, and physical and verbal aggressiveness. Over several months, she developed verbal stereotypies, gait deterioration, and double incontinence. She eventually developed mutism and an active opposition to all attempts to be fed or cared for. Benzodiazepines, olanzapine and electroconvulsive therapy were of no benefit. Magnetic resonance imaging revealed asymmetric (more severe on the right) frontotemporal, parietal, and upper brainstem atrophy. She died from sepsis without recovering from stupor seven years after the onset of symptoms. We believe that the initial behavioral disinhibition was related to the frontotemporal injury, whereas catatonic stupor reflected the progression of the degenerative process to the parietal cortices. Our case adds to the small number of cases of catatonia as a symptom of degenerative dementia. It also supports the idea that damage to the parietal cortex gives rise to pathological avoidance of which catatonic stupor represents an extreme form.
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spelling pubmed-88055942022-02-02 Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia de França, Gustavo Campos Barreto, Henrique Carneiro de Barros Paranhos, Thiago Nunes, Julio Cesar de Oliveira-Souza, Ricardo Front Neurol Neurology Catatonia is a psychomotor syndrome common to several medical and neuropsychiatric disorders. Here, we report on the case of a 95-year-old woman who underwent a radical change in personality characterized by sexual disinhibition, and physical and verbal aggressiveness. Over several months, she developed verbal stereotypies, gait deterioration, and double incontinence. She eventually developed mutism and an active opposition to all attempts to be fed or cared for. Benzodiazepines, olanzapine and electroconvulsive therapy were of no benefit. Magnetic resonance imaging revealed asymmetric (more severe on the right) frontotemporal, parietal, and upper brainstem atrophy. She died from sepsis without recovering from stupor seven years after the onset of symptoms. We believe that the initial behavioral disinhibition was related to the frontotemporal injury, whereas catatonic stupor reflected the progression of the degenerative process to the parietal cortices. Our case adds to the small number of cases of catatonia as a symptom of degenerative dementia. It also supports the idea that damage to the parietal cortex gives rise to pathological avoidance of which catatonic stupor represents an extreme form. Frontiers Media S.A. 2022-01-18 /pmc/articles/PMC8805594/ /pubmed/35115996 http://dx.doi.org/10.3389/fneur.2021.798264 Text en Copyright © 2022 de França, Barreto, Paranhos, Nunes and de Oliveira-Souza. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
de França, Gustavo Campos
Barreto, Henrique Carneiro de Barros
Paranhos, Thiago
Nunes, Julio Cesar
de Oliveira-Souza, Ricardo
Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia
title Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia
title_full Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia
title_fullStr Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia
title_full_unstemmed Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia
title_short Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia
title_sort case report: catatonic stupor in behavioral variant frontotemporal dementia
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805594/
https://www.ncbi.nlm.nih.gov/pubmed/35115996
http://dx.doi.org/10.3389/fneur.2021.798264
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