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The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina
In mice, retinal direction selectivity is organized in a map that aligns to the body and gravitational axes of optic flow, and little is known about how this map develops. We find direction selectivity maps are largely present at eye opening and develop normally in the absence of visual experience....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805704/ https://www.ncbi.nlm.nih.gov/pubmed/35021080 http://dx.doi.org/10.1016/j.celrep.2021.110225 |
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author | Tiriac, Alexandre Bistrong, Karina Pitcher, Miah N. Tworig, Joshua M. Feller, Marla B. |
author_facet | Tiriac, Alexandre Bistrong, Karina Pitcher, Miah N. Tworig, Joshua M. Feller, Marla B. |
author_sort | Tiriac, Alexandre |
collection | PubMed |
description | In mice, retinal direction selectivity is organized in a map that aligns to the body and gravitational axes of optic flow, and little is known about how this map develops. We find direction selectivity maps are largely present at eye opening and develop normally in the absence of visual experience. Remarkably, in mice lacking the beta2 subunit of neuronal nicotinic acetylcholine receptors (β2-nAChR-KO), which exhibit drastically reduced cholinergic retinal waves in the first postnatal week, selectivity to horizontal motion is absent while selectivity to vertical motion remains. We tested several possible mechanisms that could explain the loss of horizontal direction selectivity in β2-nAChR-KO mice (wave propagation bias, FRMD7 expression, starburst amacrine cell morphology), but all were found to be intact when compared with WT mice. This work establishes a role for retinal waves in the development of asymmetric circuitry that mediates retinal direction selectivity via an unknown mechanism. |
format | Online Article Text |
id | pubmed-8805704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-88057042022-02-01 The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina Tiriac, Alexandre Bistrong, Karina Pitcher, Miah N. Tworig, Joshua M. Feller, Marla B. Cell Rep Article In mice, retinal direction selectivity is organized in a map that aligns to the body and gravitational axes of optic flow, and little is known about how this map develops. We find direction selectivity maps are largely present at eye opening and develop normally in the absence of visual experience. Remarkably, in mice lacking the beta2 subunit of neuronal nicotinic acetylcholine receptors (β2-nAChR-KO), which exhibit drastically reduced cholinergic retinal waves in the first postnatal week, selectivity to horizontal motion is absent while selectivity to vertical motion remains. We tested several possible mechanisms that could explain the loss of horizontal direction selectivity in β2-nAChR-KO mice (wave propagation bias, FRMD7 expression, starburst amacrine cell morphology), but all were found to be intact when compared with WT mice. This work establishes a role for retinal waves in the development of asymmetric circuitry that mediates retinal direction selectivity via an unknown mechanism. 2022-01-11 /pmc/articles/PMC8805704/ /pubmed/35021080 http://dx.doi.org/10.1016/j.celrep.2021.110225 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Tiriac, Alexandre Bistrong, Karina Pitcher, Miah N. Tworig, Joshua M. Feller, Marla B. The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina |
title | The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina |
title_full | The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina |
title_fullStr | The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina |
title_full_unstemmed | The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina |
title_short | The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina |
title_sort | influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805704/ https://www.ncbi.nlm.nih.gov/pubmed/35021080 http://dx.doi.org/10.1016/j.celrep.2021.110225 |
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