Cargando…

The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina

In mice, retinal direction selectivity is organized in a map that aligns to the body and gravitational axes of optic flow, and little is known about how this map develops. We find direction selectivity maps are largely present at eye opening and develop normally in the absence of visual experience....

Descripción completa

Detalles Bibliográficos
Autores principales: Tiriac, Alexandre, Bistrong, Karina, Pitcher, Miah N., Tworig, Joshua M., Feller, Marla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805704/
https://www.ncbi.nlm.nih.gov/pubmed/35021080
http://dx.doi.org/10.1016/j.celrep.2021.110225
_version_ 1784643284017086464
author Tiriac, Alexandre
Bistrong, Karina
Pitcher, Miah N.
Tworig, Joshua M.
Feller, Marla B.
author_facet Tiriac, Alexandre
Bistrong, Karina
Pitcher, Miah N.
Tworig, Joshua M.
Feller, Marla B.
author_sort Tiriac, Alexandre
collection PubMed
description In mice, retinal direction selectivity is organized in a map that aligns to the body and gravitational axes of optic flow, and little is known about how this map develops. We find direction selectivity maps are largely present at eye opening and develop normally in the absence of visual experience. Remarkably, in mice lacking the beta2 subunit of neuronal nicotinic acetylcholine receptors (β2-nAChR-KO), which exhibit drastically reduced cholinergic retinal waves in the first postnatal week, selectivity to horizontal motion is absent while selectivity to vertical motion remains. We tested several possible mechanisms that could explain the loss of horizontal direction selectivity in β2-nAChR-KO mice (wave propagation bias, FRMD7 expression, starburst amacrine cell morphology), but all were found to be intact when compared with WT mice. This work establishes a role for retinal waves in the development of asymmetric circuitry that mediates retinal direction selectivity via an unknown mechanism.
format Online
Article
Text
id pubmed-8805704
institution National Center for Biotechnology Information
language English
publishDate 2022
record_format MEDLINE/PubMed
spelling pubmed-88057042022-02-01 The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina Tiriac, Alexandre Bistrong, Karina Pitcher, Miah N. Tworig, Joshua M. Feller, Marla B. Cell Rep Article In mice, retinal direction selectivity is organized in a map that aligns to the body and gravitational axes of optic flow, and little is known about how this map develops. We find direction selectivity maps are largely present at eye opening and develop normally in the absence of visual experience. Remarkably, in mice lacking the beta2 subunit of neuronal nicotinic acetylcholine receptors (β2-nAChR-KO), which exhibit drastically reduced cholinergic retinal waves in the first postnatal week, selectivity to horizontal motion is absent while selectivity to vertical motion remains. We tested several possible mechanisms that could explain the loss of horizontal direction selectivity in β2-nAChR-KO mice (wave propagation bias, FRMD7 expression, starburst amacrine cell morphology), but all were found to be intact when compared with WT mice. This work establishes a role for retinal waves in the development of asymmetric circuitry that mediates retinal direction selectivity via an unknown mechanism. 2022-01-11 /pmc/articles/PMC8805704/ /pubmed/35021080 http://dx.doi.org/10.1016/j.celrep.2021.110225 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Tiriac, Alexandre
Bistrong, Karina
Pitcher, Miah N.
Tworig, Joshua M.
Feller, Marla B.
The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina
title The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina
title_full The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina
title_fullStr The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina
title_full_unstemmed The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina
title_short The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina
title_sort influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805704/
https://www.ncbi.nlm.nih.gov/pubmed/35021080
http://dx.doi.org/10.1016/j.celrep.2021.110225
work_keys_str_mv AT tiriacalexandre theinfluenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT bistrongkarina theinfluenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT pitchermiahn theinfluenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT tworigjoshuam theinfluenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT fellermarlab theinfluenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT tiriacalexandre influenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT bistrongkarina influenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT pitchermiahn influenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT tworigjoshuam influenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina
AT fellermarlab influenceofspontaneousandvisualactivityonthedevelopmentofdirectionselectivitymapsinmouseretina