Cargando…

Anti-Liver Fibrosis Activity and the Potential Mode of Action of Ruangan Granules: Integrated Network Pharmacology and Metabolomics

Ruangan granules (RGGs) have been used to treat liver fibrosis with good clinical efficacy for many years. However, the potential mechanism of action of RGGs against liver fibrosis is still unclear. In this study, we evaluated the quality and safety of this preparation and aimed to explore the anti-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shang, Xiaofei, Yuan, Huixin, Dai, Lixia, Liu, Yang, He, Jian, Chen, Huan, Li, Hongyan, Li, Xiuhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805709/ https://www.ncbi.nlm.nih.gov/pubmed/35115923 http://dx.doi.org/10.3389/fphar.2021.754807

Ejemplares similares

Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome
por: Duan, Yanfen, et al.
Publicado: (2021)

Total flavonoids of Oldenlandia diffusa (Willd.) Roxb. suppresses the growth of hepatocellular carcinoma through endoplasmic reticulum stress-mediated autophagy and apoptosis
por: Chen, Huan, et al.
Publicado: (2022)

Anxiolytic effect of YangshenDingzhi granules: Integrated network pharmacology and hippocampal metabolomics
por: Lv, Shimeng, et al.
Publicado: (2022)

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia
por: Pang, Han-Qing, et al.
Publicado: (2018)

Integrated Metabolomics and Network Pharmacology Analysis Immunomodulatory Mechanisms of Qifenggubiao Granules
por: Guo, Bindan, et al.
Publicado: (2022)

Huangjia Ruangan Granule Inhibits Inflammation in a Rat Model with Liver Fibrosis by Regulating TNF/MAPK and NF-κB Signaling Pathways
por: Cai, Qiang, et al.
Publicado: (2022)

Exploring the Anti-Pulmonary Fibrosis Mechanism of Jingyin Granule by Network Pharmacology Strategy
por: Zhu, De-wei, et al.
Publicado: (2022)

Systems Pharmacology-Based Strategy to Investigate the Mechanism of Ruangan Lidan Decoction for Treatment of Hepatocellular Carcinoma
por: Chen, Cuilan, et al.
Publicado: (2022)

Commentary: Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures
por: Zhang, Chun, et al.
Publicado: (2022)

Effects of novel Fufang Biejia Ruangan Tablets with sheep placenta as substitute for Hominis Placenta on CCl(4)-induced liver fibrosis
por: Shen, Baode, et al.
Publicado: (2021)

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Action of Huang Qin Decoction for Treament of Diabetic Liver Injury
por: Xu, Xiaomin, et al.
Publicado: (2022)

Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis
por: Wang, Siliang, et al.
Publicado: (2021)

Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology
por: Dawood, Mona, et al.
Publicado: (2018)

Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology
por: Chen, Kuikui, et al.
Publicado: (2020)

Regulation of Shaoyao Ruangan Mixture on Intestinal Flora in Mice With Primary Liver Cancer
por: Zhen, Hongde, et al.
Publicado: (2019)

Bupleurum marginatum Wall.ex DC in Liver Fibrosis: Pharmacological Evaluation, Differential Proteomics, and Network Pharmacology
por: Liu, Xiujie, et al.
Publicado: (2018)

Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis
por: Li, Le, et al.
Publicado: (2023)

Adjuvant therapy with Huatan Sanjie Granules improves the prognosis of patients with primary liver cancer: a cohort study and the investigation of its mechanism of action based on network pharmacology
por: Yuan, Juhua, et al.
Publicado: (2023)

Exploring the mechanism of anti-chronic heart failure effect of qiweiqiangxin І granules based on metabolomics
por: Zhong, Wanru, et al.
Publicado: (2023)

Hepatoprotective Effect of San-Cao Granule on Con A-Induced Liver Injury in Mice and Mechanisms of Action Exploration
por: Yang, YuXue, et al.
Publicado: (2018)

Pharmacological effects of Bufei Jianpi granule on chronic obstructive pulmonary disease and its metabolism in rats
por: Yang, Xin-Xin, et al.
Publicado: (2022)

Pharmacological action of Hedysarum polysaccharides: a review
por: Gao, Xiang, et al.
Publicado: (2023)

Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways
por: Liu, Liming, et al.
Publicado: (2021)

Mechanism of Paeoniflorin on ANIT-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology
por: Chen, Lisheng, et al.
Publicado: (2021)

Experimental study on effect of Compound Biejia Ruangan prescription on high-resolution computerized tomographic images in bleomycin induced pulmonary fibrosis rats
por: Dong-wei, Zhang, et al.
Publicado: (2003)

Efficacy and safety of Fufang Biejia Ruangan Tablets as an adjuvant treatment for chronic hepatitis B liver fibrosis: A systematic review and meta-analysis
por: Meng, Xiangbo, et al.
Publicado: (2022)

Blocking and reversing hepatic fibrosis in patients with chronic hepatitis B treated by traditional Chinese medicine (tablets of biejia ruangan or RGT): study protocol for a randomized controlled trial
por: Qu, Jianhui, et al.
Publicado: (2014)

The mechanism of Renshen-Fuzi herb pair for treating heart failure—Integrating a cardiovascular pharmacological assessment with serum metabolomics
por: Chen, Xiaofei, et al.
Publicado: (2022)

Combined metabolomics and network pharmacology to elucidate the mechanisms of Dracorhodin Perchlorate in treating diabetic foot ulcer rats
por: Deng, Pin, et al.
Publicado: (2022)

Pharmacodynamic and Metabolomics Studies on the Effect of Kouyanqing Granule in the Treatment of Phenol-Induced Oral Ulcer Worsened by Sleep Deprivation
por: Chen, Pan, et al.
Publicado: (2020)

Network Pharmacology and Experimental Assessment to Explore the Pharmacological Mechanism of Qimai Feiluoping Decoction Against Pulmonary Fibrosis
por: Yang, Yingying, et al.
Publicado: (2021)

Qingda Granule Attenuates Angiotensin II-Induced Renal Apoptosis and Activation of the p53 Pathway
por: Long, Linzi, et al.
Publicado: (2022)

Minimal Hepatic Encephalopathy and Biejia-Ruangan Are Associated with First Hospital Readmission in Nonalcoholic Cirrhosis Patients
por: Jiang, Ting-Ting, et al.
Publicado: (2021)

Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology
por: Luo, Wen, et al.
Publicado: (2021)

Synergistic Effect of Biejia-Ruangan on Fibrosis Regression in Patients With Chronic Hepatitis B Treated With Entecavir: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
por: Rong, Guanghua, et al.
Publicado: (2020)

Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets
por: Verma, Sonia, et al.
Publicado: (2016)

A Review of the Pharmacological Action of Astragalus Polysaccharide
por: Zheng, Yijun, et al.
Publicado: (2020)

Integrated Chemical Interpretation and Network Pharmacology Analysis to Reveal the Anti-Liver Fibrosis Effect of Penthorum chinense
por: Du, Zenan, et al.
Publicado: (2022)

Mechanism of Paeoniflorin in the Treatment of Bile Duct Ligation-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology
por: Wei, Shizhang, et al.
Publicado: (2020)

Metabolomic Analysis by Nuclear Magnetic Resonance Spectroscopy as a New Approach to Understanding Inflammation and Monitoring of Pharmacological Therapy in Children and Young Adults With Cystic Fibrosis
por: Montuschi, Paolo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mr5hnhk7612pvdb9hqkb07ot8u