New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma

Extranodal NK/T cell lymphoma (ENKL) is a rare subtype of lymphoma that shows a poor clinical outcome. The most common sites are the nasal cavity, nasopharynx, paranasal sinuses, tonsils and larynx. Because of P-glycoprotein expression on ENKL cells, ENKL is resistant to anthracycline-based chemothe...

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Autores principales: Yi, Wu, Yang, Tianxin, Lin, Sisi, Hao, Rui, Yu, Jin, Wang, Ying, Tong, Xiangming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805738/
https://www.ncbi.nlm.nih.gov/pubmed/35115837
http://dx.doi.org/10.2147/CMAR.S328846
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author Yi, Wu
Yang, Tianxin
Lin, Sisi
Hao, Rui
Yu, Jin
Wang, Ying
Tong, Xiangming
author_facet Yi, Wu
Yang, Tianxin
Lin, Sisi
Hao, Rui
Yu, Jin
Wang, Ying
Tong, Xiangming
author_sort Yi, Wu
collection PubMed
description Extranodal NK/T cell lymphoma (ENKL) is a rare subtype of lymphoma that shows a poor clinical outcome. The most common sites are the nasal cavity, nasopharynx, paranasal sinuses, tonsils and larynx. Because of P-glycoprotein expression on ENKL cells, ENKL is resistant to anthracycline-based chemotherapy. L-asparaginase-based chemotherapy with or without radiotherapy shows promising outcomes for advanced ENKL, but has limited efficacy in relapsed/refractory ENKL. immune-checkpoint inhibitors, histone deacetylase inhibitors, and monoclonal antibodies are being investigated. In this review, we summarize the new treatments for ENKL.
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spelling pubmed-88057382022-02-02 New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma Yi, Wu Yang, Tianxin Lin, Sisi Hao, Rui Yu, Jin Wang, Ying Tong, Xiangming Cancer Manag Res Review Extranodal NK/T cell lymphoma (ENKL) is a rare subtype of lymphoma that shows a poor clinical outcome. The most common sites are the nasal cavity, nasopharynx, paranasal sinuses, tonsils and larynx. Because of P-glycoprotein expression on ENKL cells, ENKL is resistant to anthracycline-based chemotherapy. L-asparaginase-based chemotherapy with or without radiotherapy shows promising outcomes for advanced ENKL, but has limited efficacy in relapsed/refractory ENKL. immune-checkpoint inhibitors, histone deacetylase inhibitors, and monoclonal antibodies are being investigated. In this review, we summarize the new treatments for ENKL. Dove 2022-01-28 /pmc/articles/PMC8805738/ /pubmed/35115837 http://dx.doi.org/10.2147/CMAR.S328846 Text en © 2022 Yi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Yi, Wu
Yang, Tianxin
Lin, Sisi
Hao, Rui
Yu, Jin
Wang, Ying
Tong, Xiangming
New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma
title New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma
title_full New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma
title_fullStr New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma
title_full_unstemmed New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma
title_short New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma
title_sort new approaches for treatment of advanced extranodal nk/t-cell lymphoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805738/
https://www.ncbi.nlm.nih.gov/pubmed/35115837
http://dx.doi.org/10.2147/CMAR.S328846
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