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Antibiotic Therapy and Gastrointestinal Graft-Versus-Host Disease in the Allogeneic Stem Cell Transplantation Population
PURPOSE: Hematopoietic stem cell transplantation patients undergo rigorous courses of myeloablative chemotherapy that increase vulnerability for infections. Complications can arise in the form of graft-vs.-host disease (GvHD) manifesting in various organs, including the skin, lung, liver, and gastro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Harborside Press LLC
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805809/ https://www.ncbi.nlm.nih.gov/pubmed/35173989 http://dx.doi.org/10.6004/jadpro.2022.13.1.5 |
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author | Thomas, Jessica Bowe, Christi Dains, Joyce E. |
author_facet | Thomas, Jessica Bowe, Christi Dains, Joyce E. |
author_sort | Thomas, Jessica |
collection | PubMed |
description | PURPOSE: Hematopoietic stem cell transplantation patients undergo rigorous courses of myeloablative chemotherapy that increase vulnerability for infections. Complications can arise in the form of graft-vs.-host disease (GvHD) manifesting in various organs, including the skin, lung, liver, and gastrointestinal (GI) tract. Antibiotic therapy is generally begun in order to prevent further complications from infection but may increase the risk for acute GI GvHD. Studies that investigated antibiotic therapy and the subsequent occurrence of GI GvHD in allogeneic stem cell transplantation (aSCT) patients were reviewed. METHODS: PubMed, Scopus, and CINAHL databases were utilized. Articles published between January 1, 2009, and December 15, 2019, were included in this review. A total of 1,142 articles were retrieved. Duplicates, reviews, letters to the editors, irrelevant interventions/outcomes, and non-English articles were excluded. Inclusion criteria included individuals who were undergoing an aSCT and received antibiotic therapy. A total of seven articles were included for this review after applying the inclusion and exclusion criteria. RESULTS: The use of broad-spectrum antibiotics increased the risk of developing GI GvHD. Stool analysis when available showed a decrease in the diversity of the gut microbiome, which in turn led to the increase in acute GvHD. IMPLICATIONS: The increased risk of GvHD may have implications for the standard of care therapy, which includes treatment, for infections during SCTs. Providers will need to weigh the risk vs. benefit of antibiotic therapy and exercise judicious selection of antibiotics prior to engraftment. |
format | Online Article Text |
id | pubmed-8805809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Harborside Press LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-88058092022-02-15 Antibiotic Therapy and Gastrointestinal Graft-Versus-Host Disease in the Allogeneic Stem Cell Transplantation Population Thomas, Jessica Bowe, Christi Dains, Joyce E. J Adv Pract Oncol Review PURPOSE: Hematopoietic stem cell transplantation patients undergo rigorous courses of myeloablative chemotherapy that increase vulnerability for infections. Complications can arise in the form of graft-vs.-host disease (GvHD) manifesting in various organs, including the skin, lung, liver, and gastrointestinal (GI) tract. Antibiotic therapy is generally begun in order to prevent further complications from infection but may increase the risk for acute GI GvHD. Studies that investigated antibiotic therapy and the subsequent occurrence of GI GvHD in allogeneic stem cell transplantation (aSCT) patients were reviewed. METHODS: PubMed, Scopus, and CINAHL databases were utilized. Articles published between January 1, 2009, and December 15, 2019, were included in this review. A total of 1,142 articles were retrieved. Duplicates, reviews, letters to the editors, irrelevant interventions/outcomes, and non-English articles were excluded. Inclusion criteria included individuals who were undergoing an aSCT and received antibiotic therapy. A total of seven articles were included for this review after applying the inclusion and exclusion criteria. RESULTS: The use of broad-spectrum antibiotics increased the risk of developing GI GvHD. Stool analysis when available showed a decrease in the diversity of the gut microbiome, which in turn led to the increase in acute GvHD. IMPLICATIONS: The increased risk of GvHD may have implications for the standard of care therapy, which includes treatment, for infections during SCTs. Providers will need to weigh the risk vs. benefit of antibiotic therapy and exercise judicious selection of antibiotics prior to engraftment. Harborside Press LLC 2022-01 2022-02-01 /pmc/articles/PMC8805809/ /pubmed/35173989 http://dx.doi.org/10.6004/jadpro.2022.13.1.5 Text en © 2022 Harborside™ https://creativecommons.org/licenses/by-nc-nd/3.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial Non-Derivative License, which permits unrestricted non-commercial and non-derivative use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Thomas, Jessica Bowe, Christi Dains, Joyce E. Antibiotic Therapy and Gastrointestinal Graft-Versus-Host Disease in the Allogeneic Stem Cell Transplantation Population |
title | Antibiotic Therapy and Gastrointestinal Graft-Versus-Host Disease in the Allogeneic Stem Cell Transplantation Population |
title_full | Antibiotic Therapy and Gastrointestinal Graft-Versus-Host Disease in the Allogeneic Stem Cell Transplantation Population |
title_fullStr | Antibiotic Therapy and Gastrointestinal Graft-Versus-Host Disease in the Allogeneic Stem Cell Transplantation Population |
title_full_unstemmed | Antibiotic Therapy and Gastrointestinal Graft-Versus-Host Disease in the Allogeneic Stem Cell Transplantation Population |
title_short | Antibiotic Therapy and Gastrointestinal Graft-Versus-Host Disease in the Allogeneic Stem Cell Transplantation Population |
title_sort | antibiotic therapy and gastrointestinal graft-versus-host disease in the allogeneic stem cell transplantation population |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805809/ https://www.ncbi.nlm.nih.gov/pubmed/35173989 http://dx.doi.org/10.6004/jadpro.2022.13.1.5 |
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