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Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases
Viral diseases are prominent among the widely spread infections threatening human well-being. Real-life clinical successes of the few available therapeutics are challenged by pathogenic resistance and suboptimal delivery to target sites. Nanotechnology has aided the design of functionalised and non-...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806017/ https://www.ncbi.nlm.nih.gov/pubmed/35815068 http://dx.doi.org/10.1016/j.crchbi.2022.100021 |
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author | Ayipo, Yusuf Oloruntoyin Bakare, Ajibola Abdulahi Badeggi, Umar Muhammad Jimoh, Akeem Adebayo Lawal, Amudat Mordi, Mohd Nizam |
author_facet | Ayipo, Yusuf Oloruntoyin Bakare, Ajibola Abdulahi Badeggi, Umar Muhammad Jimoh, Akeem Adebayo Lawal, Amudat Mordi, Mohd Nizam |
author_sort | Ayipo, Yusuf Oloruntoyin |
collection | PubMed |
description | Viral diseases are prominent among the widely spread infections threatening human well-being. Real-life clinical successes of the few available therapeutics are challenged by pathogenic resistance and suboptimal delivery to target sites. Nanotechnology has aided the design of functionalised and non-functionalised Au and Ag nanobiomaterials through physical, chemical and biological (green synthesis) methods with improved antiviral efficacy and delivery. In this review, innovative designs as well as interesting antiviral activities of the nanotechnology-inclined biomaterials of Au and Ag, reported in the last 5 years were critically overviewed against several viral diseases affecting man. These include influenza, respiratory syncytial, adenovirus, severe acute respiratory syndromes (SARS), rotavirus, norovirus, measles, chikungunya, HIV, herpes simplex virus, dengue, polio, enterovirus and rift valley fever virus. Notably identified among the nanotechnologically designed promising antiviral agents include AuNP-M2e peptide vaccine, AgNP of cinnamon bark extract and AgNP of oseltamivir for influenza, PVP coated AgNP for RSV, PVP-AgNPs for SARS-CoV-2, AuNRs of a peptide pregnancy-inducedhypertension and AuNP nanocarriers of antigen for MERS-CoV and SARS-CoV respectively. Others are AgNPs of collagen and Bacillus subtilis for rotavirus, AgNPs labelled Ag30–SiO(2) for murine norovirus in water, AuNPs of Allium sativum and AgNPs of ribavirin for measles, AgNPs of Citrus limetta and Andrographis Paniculata for Chikungunya, AuNPs of efavirenz and stavudine, and AgNPs-curcumin for HIV, NPAuG3-S8 for HSV, AgNPs of Moringa oleifera and Bruguiera cylindrica for dengue while AgNPs of polyethyleneimine and siRNA analogues displayed potency against enterovirus. The highlighted candidates are recommended for further translational studies towards antiviral therapeutic designs. |
format | Online Article Text |
id | pubmed-8806017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Author(s). Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88060172022-02-02 Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases Ayipo, Yusuf Oloruntoyin Bakare, Ajibola Abdulahi Badeggi, Umar Muhammad Jimoh, Akeem Adebayo Lawal, Amudat Mordi, Mohd Nizam Curr Res Chem Biol Article Viral diseases are prominent among the widely spread infections threatening human well-being. Real-life clinical successes of the few available therapeutics are challenged by pathogenic resistance and suboptimal delivery to target sites. Nanotechnology has aided the design of functionalised and non-functionalised Au and Ag nanobiomaterials through physical, chemical and biological (green synthesis) methods with improved antiviral efficacy and delivery. In this review, innovative designs as well as interesting antiviral activities of the nanotechnology-inclined biomaterials of Au and Ag, reported in the last 5 years were critically overviewed against several viral diseases affecting man. These include influenza, respiratory syncytial, adenovirus, severe acute respiratory syndromes (SARS), rotavirus, norovirus, measles, chikungunya, HIV, herpes simplex virus, dengue, polio, enterovirus and rift valley fever virus. Notably identified among the nanotechnologically designed promising antiviral agents include AuNP-M2e peptide vaccine, AgNP of cinnamon bark extract and AgNP of oseltamivir for influenza, PVP coated AgNP for RSV, PVP-AgNPs for SARS-CoV-2, AuNRs of a peptide pregnancy-inducedhypertension and AuNP nanocarriers of antigen for MERS-CoV and SARS-CoV respectively. Others are AgNPs of collagen and Bacillus subtilis for rotavirus, AgNPs labelled Ag30–SiO(2) for murine norovirus in water, AuNPs of Allium sativum and AgNPs of ribavirin for measles, AgNPs of Citrus limetta and Andrographis Paniculata for Chikungunya, AuNPs of efavirenz and stavudine, and AgNPs-curcumin for HIV, NPAuG3-S8 for HSV, AgNPs of Moringa oleifera and Bruguiera cylindrica for dengue while AgNPs of polyethyleneimine and siRNA analogues displayed potency against enterovirus. The highlighted candidates are recommended for further translational studies towards antiviral therapeutic designs. The Author(s). Published by Elsevier B.V. 2022 2022-02-01 /pmc/articles/PMC8806017/ /pubmed/35815068 http://dx.doi.org/10.1016/j.crchbi.2022.100021 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Ayipo, Yusuf Oloruntoyin Bakare, Ajibola Abdulahi Badeggi, Umar Muhammad Jimoh, Akeem Adebayo Lawal, Amudat Mordi, Mohd Nizam Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases |
title | Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases |
title_full | Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases |
title_fullStr | Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases |
title_full_unstemmed | Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases |
title_short | Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases |
title_sort | recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806017/ https://www.ncbi.nlm.nih.gov/pubmed/35815068 http://dx.doi.org/10.1016/j.crchbi.2022.100021 |
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