Cargando…

High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic disease associated with worse clinical presentation. However, the current investigation practices in Ethiopia have limitations to demonstrate the scope of the clinical burden. Hence, this study was aimed at assessing the glycemic status and co...

Descripción completa

Detalles Bibliográficos
Autores principales: Gebreyesus, Hagos Amare, Abreha, Girmatsion Fisseha, Besherae, Sintayehu Degu, Abera, Merhawit Atsbha, Weldegerima, Abraha Hailu, Gidey, Aregawi Haileslassie, Bezabih, Afework Mulugeta, Lemma, Tefera Belachew, Nigatu, Tsinuel Girma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806058/
https://www.ncbi.nlm.nih.gov/pubmed/35104300
http://dx.doi.org/10.1371/journal.pone.0262610
_version_ 1784643364333813760
author Gebreyesus, Hagos Amare
Abreha, Girmatsion Fisseha
Besherae, Sintayehu Degu
Abera, Merhawit Atsbha
Weldegerima, Abraha Hailu
Gidey, Aregawi Haileslassie
Bezabih, Afework Mulugeta
Lemma, Tefera Belachew
Nigatu, Tsinuel Girma
author_facet Gebreyesus, Hagos Amare
Abreha, Girmatsion Fisseha
Besherae, Sintayehu Degu
Abera, Merhawit Atsbha
Weldegerima, Abraha Hailu
Gidey, Aregawi Haileslassie
Bezabih, Afework Mulugeta
Lemma, Tefera Belachew
Nigatu, Tsinuel Girma
author_sort Gebreyesus, Hagos Amare
collection PubMed
description BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic disease associated with worse clinical presentation. However, the current investigation practices in Ethiopia have limitations to demonstrate the scope of the clinical burden. Hence, this study was aimed at assessing the glycemic status and coronary heart disease (CHD) risk of persons with T2DM using HbA1c and atherogenic index of plasma (AIP). METHOD: This institution-based cross-sectional study was conducted among 421 adults with T2DM from September to November 2019. Demographic, socioeconomic, and lifestyle data were collected through a face-to-face interview. Clinical information was retrieved from medical records whereas anthropometric and biochemical measurements were performed using the WHO protocols. Glycemic status was determined using HbA1c and CHD risk assessed using an atherogenic index of plasma (AIP). Gaussian variables were expressed using mean and standard deviation (SD), Log-normal variables using geometric mean and 95% CI and non- Gaussian variables using median and interquartile ranges. Categorical variables were summarized using absolute frequencies and percentages. Multivariable logistic regression was used to identify factors associated with glycemic control with a statistical significance set at 5%. RESULT: A total of 195 male and 226 female subjects were involved in this study. The results demonstrated that 77% (324) had HbA1c value ≥7% and 87.2% (367) had high atherogenic risk for CHD. Besides, 57% and 67.9% of persons with T2DM had metabolic syndrome according to International Diabetes Federation (IDF) and the National Cholesterol Education Program—Adult treatment panel III (NCEP-ATP III) criteria, respectively. About 36.8% had one or more comorbidities. Having healthy eating behavior [AOR 1.95; CI 1.11–3.43] and taking metformin [AOR 4.88; CI 1.91–12.44] were associated with better glycemic outcomes. CONCLUSION: High AIP level concomitant with poor glycemic control indicates increased risk for coronary heart disease among persons with T2DM in Northern Ethiopia.
format Online
Article
Text
id pubmed-8806058
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-88060582022-02-02 High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia Gebreyesus, Hagos Amare Abreha, Girmatsion Fisseha Besherae, Sintayehu Degu Abera, Merhawit Atsbha Weldegerima, Abraha Hailu Gidey, Aregawi Haileslassie Bezabih, Afework Mulugeta Lemma, Tefera Belachew Nigatu, Tsinuel Girma PLoS One Research Article BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic disease associated with worse clinical presentation. However, the current investigation practices in Ethiopia have limitations to demonstrate the scope of the clinical burden. Hence, this study was aimed at assessing the glycemic status and coronary heart disease (CHD) risk of persons with T2DM using HbA1c and atherogenic index of plasma (AIP). METHOD: This institution-based cross-sectional study was conducted among 421 adults with T2DM from September to November 2019. Demographic, socioeconomic, and lifestyle data were collected through a face-to-face interview. Clinical information was retrieved from medical records whereas anthropometric and biochemical measurements were performed using the WHO protocols. Glycemic status was determined using HbA1c and CHD risk assessed using an atherogenic index of plasma (AIP). Gaussian variables were expressed using mean and standard deviation (SD), Log-normal variables using geometric mean and 95% CI and non- Gaussian variables using median and interquartile ranges. Categorical variables were summarized using absolute frequencies and percentages. Multivariable logistic regression was used to identify factors associated with glycemic control with a statistical significance set at 5%. RESULT: A total of 195 male and 226 female subjects were involved in this study. The results demonstrated that 77% (324) had HbA1c value ≥7% and 87.2% (367) had high atherogenic risk for CHD. Besides, 57% and 67.9% of persons with T2DM had metabolic syndrome according to International Diabetes Federation (IDF) and the National Cholesterol Education Program—Adult treatment panel III (NCEP-ATP III) criteria, respectively. About 36.8% had one or more comorbidities. Having healthy eating behavior [AOR 1.95; CI 1.11–3.43] and taking metformin [AOR 4.88; CI 1.91–12.44] were associated with better glycemic outcomes. CONCLUSION: High AIP level concomitant with poor glycemic control indicates increased risk for coronary heart disease among persons with T2DM in Northern Ethiopia. Public Library of Science 2022-02-01 /pmc/articles/PMC8806058/ /pubmed/35104300 http://dx.doi.org/10.1371/journal.pone.0262610 Text en © 2022 Gebreyesus et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gebreyesus, Hagos Amare
Abreha, Girmatsion Fisseha
Besherae, Sintayehu Degu
Abera, Merhawit Atsbha
Weldegerima, Abraha Hailu
Gidey, Aregawi Haileslassie
Bezabih, Afework Mulugeta
Lemma, Tefera Belachew
Nigatu, Tsinuel Girma
High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia
title High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia
title_full High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia
title_fullStr High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia
title_full_unstemmed High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia
title_short High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia
title_sort high atherogenic risk concomitant with elevated hba1c among persons with type 2 diabetes mellitus in north ethiopia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806058/
https://www.ncbi.nlm.nih.gov/pubmed/35104300
http://dx.doi.org/10.1371/journal.pone.0262610
work_keys_str_mv AT gebreyesushagosamare highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia
AT abrehagirmatsionfisseha highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia
AT besheraesintayehudegu highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia
AT aberamerhawitatsbha highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia
AT weldegerimaabrahahailu highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia
AT gideyaregawihaileslassie highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia
AT bezabihafeworkmulugeta highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia
AT lemmateferabelachew highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia
AT nigatutsinuelgirma highatherogenicriskconcomitantwithelevatedhba1camongpersonswithtype2diabetesmellitusinnorthethiopia