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Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association

We aimed to examine the association between serum cotinine and leukocyte telomere length (LTL) and the intermediate effects of body mass index (BMI) and C-reactive protein (CRP) on modulating the association. This study included 4,047 adults from the 1999 to 2002 National Health and Nutrition Examin...

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Autores principales: Gao, Xiao, Kong, Yawei, Li, Shengxu, Dong, Shiqiu, Huang, Xinyu, Qi, Deyu, Zhang, Tao, Yan, Yinkun, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806079/
https://www.ncbi.nlm.nih.gov/pubmed/35115918
http://dx.doi.org/10.3389/fnagi.2021.827465
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author Gao, Xiao
Kong, Yawei
Li, Shengxu
Dong, Shiqiu
Huang, Xinyu
Qi, Deyu
Zhang, Tao
Yan, Yinkun
Chen, Wei
author_facet Gao, Xiao
Kong, Yawei
Li, Shengxu
Dong, Shiqiu
Huang, Xinyu
Qi, Deyu
Zhang, Tao
Yan, Yinkun
Chen, Wei
author_sort Gao, Xiao
collection PubMed
description We aimed to examine the association between serum cotinine and leukocyte telomere length (LTL) and the intermediate effects of body mass index (BMI) and C-reactive protein (CRP) on modulating the association. This study included 4,047 adults from the 1999 to 2002 National Health and Nutrition Examination Survey. In the combined sample, after adjusting for age, race, sex, physical activity, and alcohol use, the total effect of serum cotinine on LTL was significant (standardized regression coefficient, β = −0.049, p = 0.001) without BMI and CRP included in the model. With inclusion of BMI but without CRP in the model, the direct effect of cotinine on LTL in its absolute value increased to β = −0.053 (p < 0.001), and the suppression effect of BMI was estimated at 8.8%. With inclusion of CRP but without BMI in the model, the direct effect of cotinine on LTL in its absolute value decreased to β = −0.040 (p = 0.008), and the mediation effect of CRP was estimated at 16.9%. With inclusion of both BMI and CRP in the model, BMI and CRP still had significant suppression and mediation effects, respectively, on the cotinine-LTL association. These findings suggest that weight and inflammation have different roles in the inverse association between serum cotinine and LTL.
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spelling pubmed-88060792022-02-02 Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association Gao, Xiao Kong, Yawei Li, Shengxu Dong, Shiqiu Huang, Xinyu Qi, Deyu Zhang, Tao Yan, Yinkun Chen, Wei Front Aging Neurosci Neuroscience We aimed to examine the association between serum cotinine and leukocyte telomere length (LTL) and the intermediate effects of body mass index (BMI) and C-reactive protein (CRP) on modulating the association. This study included 4,047 adults from the 1999 to 2002 National Health and Nutrition Examination Survey. In the combined sample, after adjusting for age, race, sex, physical activity, and alcohol use, the total effect of serum cotinine on LTL was significant (standardized regression coefficient, β = −0.049, p = 0.001) without BMI and CRP included in the model. With inclusion of BMI but without CRP in the model, the direct effect of cotinine on LTL in its absolute value increased to β = −0.053 (p < 0.001), and the suppression effect of BMI was estimated at 8.8%. With inclusion of CRP but without BMI in the model, the direct effect of cotinine on LTL in its absolute value decreased to β = −0.040 (p = 0.008), and the mediation effect of CRP was estimated at 16.9%. With inclusion of both BMI and CRP in the model, BMI and CRP still had significant suppression and mediation effects, respectively, on the cotinine-LTL association. These findings suggest that weight and inflammation have different roles in the inverse association between serum cotinine and LTL. Frontiers Media S.A. 2022-01-18 /pmc/articles/PMC8806079/ /pubmed/35115918 http://dx.doi.org/10.3389/fnagi.2021.827465 Text en Copyright © 2022 Gao, Kong, Li, Dong, Huang, Qi, Zhang, Yan and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gao, Xiao
Kong, Yawei
Li, Shengxu
Dong, Shiqiu
Huang, Xinyu
Qi, Deyu
Zhang, Tao
Yan, Yinkun
Chen, Wei
Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association
title Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association
title_full Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association
title_fullStr Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association
title_full_unstemmed Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association
title_short Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association
title_sort intermediate effects of body mass index and c-reactive protein on the serum cotinine- leukocyte telomere length association
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806079/
https://www.ncbi.nlm.nih.gov/pubmed/35115918
http://dx.doi.org/10.3389/fnagi.2021.827465
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