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Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of malaria. HAP2 has three extracellular domains, arrang...

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Detalles Bibliográficos
Autores principales:	Feng, Juan, Dong, Xianchi, DeCosta, Adam, Su, Yang, Angrisano, Fiona, Sala, Katarzyna A, Blagborough, Andrew M, Lu, Chafen, Springer, Timothy A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806182/ https://www.ncbi.nlm.nih.gov/pubmed/34939934 http://dx.doi.org/10.7554/eLife.74707

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