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Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'

We thank Keith Matthews and Stephen Larcombe for their thoughtful comment, which follows the good tradition of public scientific discourse (Matthews and Larcombe, 2022). While their remarks have prompted us to take another critical look at our data, we think that they neither alter our conclusions n...

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Detalles Bibliográficos
Autores principales: Lisack, Jaime, Morriswood, Brooke, Engstler, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806184/
https://www.ncbi.nlm.nih.gov/pubmed/35103593
http://dx.doi.org/10.7554/eLife.75922
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author Lisack, Jaime
Morriswood, Brooke
Engstler, Markus
author_facet Lisack, Jaime
Morriswood, Brooke
Engstler, Markus
author_sort Lisack, Jaime
collection PubMed
description We thank Keith Matthews and Stephen Larcombe for their thoughtful comment, which follows the good tradition of public scientific discourse (Matthews and Larcombe, 2022). While their remarks have prompted us to take another critical look at our data, we think that they neither alter our conclusions nor offer a practical alternative explanation. In essence, we see two possible interpretations of our experiments: either the trypanosome life cycle can accommodate a more flexible role for the slender stage, or the definition of the stumpy stage needs to be radically changed. While the first interpretation – which we favour – would not falsify any published work, the second one – which Matthews and Larcombe are proposing – would contradict the literature. Hence, we favour a model with an unexpected phenotypic plasticity for the slender stage and a certain degree of stochasticity in the trypanosome life cycle.
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spelling pubmed-88061842022-02-02 Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei' Lisack, Jaime Morriswood, Brooke Engstler, Markus eLife Cell Biology We thank Keith Matthews and Stephen Larcombe for their thoughtful comment, which follows the good tradition of public scientific discourse (Matthews and Larcombe, 2022). While their remarks have prompted us to take another critical look at our data, we think that they neither alter our conclusions nor offer a practical alternative explanation. In essence, we see two possible interpretations of our experiments: either the trypanosome life cycle can accommodate a more flexible role for the slender stage, or the definition of the stumpy stage needs to be radically changed. While the first interpretation – which we favour – would not falsify any published work, the second one – which Matthews and Larcombe are proposing – would contradict the literature. Hence, we favour a model with an unexpected phenotypic plasticity for the slender stage and a certain degree of stochasticity in the trypanosome life cycle. eLife Sciences Publications, Ltd 2022-02-01 /pmc/articles/PMC8806184/ /pubmed/35103593 http://dx.doi.org/10.7554/eLife.75922 Text en © 2022, Lisack et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Lisack, Jaime
Morriswood, Brooke
Engstler, Markus
Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'
title Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'
title_full Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'
title_fullStr Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'
title_full_unstemmed Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'
title_short Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'
title_sort response to comment on 'unexpected plasticity in the life cycle of trypanosoma brucei'
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806184/
https://www.ncbi.nlm.nih.gov/pubmed/35103593
http://dx.doi.org/10.7554/eLife.75922
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