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MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2)
MicroRNAs (miRNAs) dysregulation contributes to tumorigenesis, and it is reported that abnormal miR-92a-3p expression participates in multiple cancers’ occurrence and progression. This study focuses on miR-92a-3p’s functions and regulatory mechanism in breast cancer (BC). The current study proved mi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806219/ https://www.ncbi.nlm.nih.gov/pubmed/34082648 http://dx.doi.org/10.1080/21655979.2021.1924543 |
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author | Jinghua, Huang Qinghua, Zhou Chenchen, Chen Lili, Chen Xiao, Xu Yunfei, Wang Zhengzhe, An Changxiu, Lin Hui, Han |
author_facet | Jinghua, Huang Qinghua, Zhou Chenchen, Chen Lili, Chen Xiao, Xu Yunfei, Wang Zhengzhe, An Changxiu, Lin Hui, Han |
author_sort | Jinghua, Huang |
collection | PubMed |
description | MicroRNAs (miRNAs) dysregulation contributes to tumorigenesis, and it is reported that abnormal miR-92a-3p expression participates in multiple cancers’ occurrence and progression. This study focuses on miR-92a-3p’s functions and regulatory mechanism in breast cancer (BC). The current study proved miR-92a-3p expression was enhanced in BC tissues and cells, and its high expression was related to increased TNM stage and larger tumor size of BC patients. Functionally, transfection of miR-92a-3p mimics facilitated BC cell proliferation and metastasis, yet transfection of miR-92a-3p inhibitors functioned oppositely. In addition, BTG2 was verified as a direct miR-92a-3p target in BC cells. This research indicated that miR-92a-3p facilitates BC cell proliferation and metastasis through repressing BTG2 expression. |
format | Online Article Text |
id | pubmed-8806219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88062192022-02-02 MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2) Jinghua, Huang Qinghua, Zhou Chenchen, Chen Lili, Chen Xiao, Xu Yunfei, Wang Zhengzhe, An Changxiu, Lin Hui, Han Bioengineered Research Paper MicroRNAs (miRNAs) dysregulation contributes to tumorigenesis, and it is reported that abnormal miR-92a-3p expression participates in multiple cancers’ occurrence and progression. This study focuses on miR-92a-3p’s functions and regulatory mechanism in breast cancer (BC). The current study proved miR-92a-3p expression was enhanced in BC tissues and cells, and its high expression was related to increased TNM stage and larger tumor size of BC patients. Functionally, transfection of miR-92a-3p mimics facilitated BC cell proliferation and metastasis, yet transfection of miR-92a-3p inhibitors functioned oppositely. In addition, BTG2 was verified as a direct miR-92a-3p target in BC cells. This research indicated that miR-92a-3p facilitates BC cell proliferation and metastasis through repressing BTG2 expression. Taylor & Francis 2021-06-03 /pmc/articles/PMC8806219/ /pubmed/34082648 http://dx.doi.org/10.1080/21655979.2021.1924543 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Jinghua, Huang Qinghua, Zhou Chenchen, Chen Lili, Chen Xiao, Xu Yunfei, Wang Zhengzhe, An Changxiu, Lin Hui, Han MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2) |
title | MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2) |
title_full | MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2) |
title_fullStr | MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2) |
title_full_unstemmed | MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2) |
title_short | MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2) |
title_sort | microrna mir-92a-3p regulates breast cancer cell proliferation and metastasis via regulating b-cell translocation gene 2 (btg2) |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806219/ https://www.ncbi.nlm.nih.gov/pubmed/34082648 http://dx.doi.org/10.1080/21655979.2021.1924543 |
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