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Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank

INTRODUCTION: Pancreatitis is a complex syndrome that results from many etiologies. Large well-characterized cohorts are needed to further understand disease risk and prognosis. METHODS: A pancreatitis cohort of more than 4,200 patients and 24,000 controls were identified in the UK BioBank (UKBB) co...

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Autores principales: Spagnolo, Daniel M., Greer, Phil J., Ohlsen, Celeste Shelton, Mance, Shannon, Ellison, Mitchell, Breze, Cameron, Busby, Ben, Whitcomb, David C., Haupt, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806365/
https://www.ncbi.nlm.nih.gov/pubmed/35060944
http://dx.doi.org/10.14309/ctg.0000000000000455
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author Spagnolo, Daniel M.
Greer, Phil J.
Ohlsen, Celeste Shelton
Mance, Shannon
Ellison, Mitchell
Breze, Cameron
Busby, Ben
Whitcomb, David C.
Haupt, Mark
author_facet Spagnolo, Daniel M.
Greer, Phil J.
Ohlsen, Celeste Shelton
Mance, Shannon
Ellison, Mitchell
Breze, Cameron
Busby, Ben
Whitcomb, David C.
Haupt, Mark
author_sort Spagnolo, Daniel M.
collection PubMed
description INTRODUCTION: Pancreatitis is a complex syndrome that results from many etiologies. Large well-characterized cohorts are needed to further understand disease risk and prognosis. METHODS: A pancreatitis cohort of more than 4,200 patients and 24,000 controls were identified in the UK BioBank (UKBB) consortium. A descriptive analysis was completed, comparing patients with acute (AP) and chronic pancreatitis (CP). The Toxic-metabolic, Idiopathic, Genetic, Autoimmune, Recurrent, and severe pancreatitis and Obstructive checklist Version 2 classification was applied to patients with AP and CP and compared with the control population. RESULTS: CP prevalence in the UKBB is 163 per 100,000. AP incidence increased from 21.4/100,000 per year from 2001 to 2005 to 48.2/100,000 per year between 2016 and 2020. Gallstones and smoking were confirmed as key risk factors for AP and CP, respectively. Both populations carry multiple risk factors and a high burden of comorbidities, including benign and malignant neoplastic disorders. DISCUSSION: The UKBB serves as a rich cohort to evaluate pancreatitis. Disease burden of AP and CP was high in this population. The association of common risk factors identified in other cohort studies was confirmed in this study. Further analysis is needed to link genomic risks and biomarkers with disease features in this population.
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spelling pubmed-88063652022-02-02 Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank Spagnolo, Daniel M. Greer, Phil J. Ohlsen, Celeste Shelton Mance, Shannon Ellison, Mitchell Breze, Cameron Busby, Ben Whitcomb, David C. Haupt, Mark Clin Transl Gastroenterol Article INTRODUCTION: Pancreatitis is a complex syndrome that results from many etiologies. Large well-characterized cohorts are needed to further understand disease risk and prognosis. METHODS: A pancreatitis cohort of more than 4,200 patients and 24,000 controls were identified in the UK BioBank (UKBB) consortium. A descriptive analysis was completed, comparing patients with acute (AP) and chronic pancreatitis (CP). The Toxic-metabolic, Idiopathic, Genetic, Autoimmune, Recurrent, and severe pancreatitis and Obstructive checklist Version 2 classification was applied to patients with AP and CP and compared with the control population. RESULTS: CP prevalence in the UKBB is 163 per 100,000. AP incidence increased from 21.4/100,000 per year from 2001 to 2005 to 48.2/100,000 per year between 2016 and 2020. Gallstones and smoking were confirmed as key risk factors for AP and CP, respectively. Both populations carry multiple risk factors and a high burden of comorbidities, including benign and malignant neoplastic disorders. DISCUSSION: The UKBB serves as a rich cohort to evaluate pancreatitis. Disease burden of AP and CP was high in this population. The association of common risk factors identified in other cohort studies was confirmed in this study. Further analysis is needed to link genomic risks and biomarkers with disease features in this population. Wolters Kluwer 2022-01-19 /pmc/articles/PMC8806365/ /pubmed/35060944 http://dx.doi.org/10.14309/ctg.0000000000000455 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Spagnolo, Daniel M.
Greer, Phil J.
Ohlsen, Celeste Shelton
Mance, Shannon
Ellison, Mitchell
Breze, Cameron
Busby, Ben
Whitcomb, David C.
Haupt, Mark
Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank
title Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank
title_full Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank
title_fullStr Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank
title_full_unstemmed Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank
title_short Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank
title_sort acute and chronic pancreatitis disease prevalence, classification, and comorbidities: a cohort study of the uk biobank
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806365/
https://www.ncbi.nlm.nih.gov/pubmed/35060944
http://dx.doi.org/10.14309/ctg.0000000000000455
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