Potential therapeutic target genes for systemic lupus erythematosus: a bioinformatics analysis

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs. However, the underlying etiology and mechanisms remain unclear. This study was performed to identify potential therapeutic targets for SLE using bioinformatics methods. First, 584 differentially expressed g...

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Detalles Bibliográficos
Autores principales: Yu, Yun, Liu, Liang, Hu, Long-Long, Yu, Ling-Ling, Li, Jun-Pei, Rao, Jing-an, Zhu, Ling-Juan, Liang, Qian, Zhang, Rong-Wei, Bao, Hui-Hui, Cheng, Xiao-Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806421/
https://www.ncbi.nlm.nih.gov/pubmed/34180358
http://dx.doi.org/10.1080/21655979.2021.1939637
Descripción
Sumario:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs. However, the underlying etiology and mechanisms remain unclear. This study was performed to identify potential therapeutic targets for SLE using bioinformatics methods. First, 584 differentially expressed genes were identified based on the GSE61635 dataset. Tissue-specific analyses, enrichment analyses, and Protein–Protein interaction network were successively conducted. Furthermore, ELISA was performed to confirm the expression levels of key genes in the control and SLE blood samples. The findings revealed that tissue-specific expression of markers of the hematological system (25.5%, 28/110) varied significantly. CCL2, MMP9, and RSAD2 expression was markedly increased in the SLE samples compared with controls. In conclusion, the identified key genes (CCL2, MMP9, and RSAD2) may act as possible therapeutic targets for the treatment of SLE.

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