Cargando…

KLF9 (Kruppel Like Factor 9) induced PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3) downregulation inhibits the proliferation, metastasis and aerobic glycolysis of cutaneous squamous cell carcinoma cells

Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer in humans with increasing incidence. In this paper, we focused on the effects of krueppel-like factor 9 (KLF9) on the progression of CSCC cells by binding to PFKFB3. mRNA and protein expressions of KLF9 and PFKFB3 in huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xing, Jiahua, Jia, Ziqi, Xu, Yichi, Chen, Muzi, Yang, Zheng, Chen, Youbai, Han, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806463/ https://www.ncbi.nlm.nih.gov/pubmed/34612136 http://dx.doi.org/10.1080/21655979.2021.1980644

Ejemplares similares

Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
por: Liu, Miao, et al.
Publicado: (2021)

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer
por: Yi, Mei, et al.
Publicado: (2018)

Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3
por: Kong, Liang, et al.
Publicado: (2019)

Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells
por: Carlet, Michela, et al.
Publicado: (2010)

Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2)
por: Ji, Fang, et al.
Publicado: (2022)

Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis
por: Tillie, Renée J. H. A., et al.
Publicado: (2021)

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth
por: Chesney, Jason, et al.
Publicado: (2014)

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
por: Klarer, Alden C, et al.
Publicado: (2014)

International practices in the dietary management of fructose 1-6 biphosphatase deficiency
por: Pinto, A., et al.
Publicado: (2018)

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB4) as a Novel Autophagy Regulator by High Content shRNA Screening
por: Strohecker, Anne M., et al.
Publicado: (2015)

Simultaneous inhibition of the estrogen receptor and 6-phosphofructo-2-kinase (PFKFB3) for the treatment of ER+ breast cancer
por: Imbert-Fernandez, Yoannis, et al.
Publicado: (2014)

The role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 in esophageal squamous cell carcinoma
por: Bao, Junhui, et al.
Publicado: (2020)

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor
por: Chesney, Jason, et al.
Publicado: (2015)

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway
por: Yan, Siyuan, et al.
Publicado: (2017)

KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells
por: Zhang, Xinhua, et al.
Publicado: (2022)

Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
por: Ros, Susana, et al.
Publicado: (2013)

Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Modulates Oscillations of Pancreatic Islet Metabolism
por: Merrins, Matthew J., et al.
Publicado: (2012)

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27
por: Yalcin, A, et al.
Publicado: (2014)

Role of PFKFB3-driven glycolysis in sepsis
por: Xiao, Min, et al.
Publicado: (2023)

Liver X Receptor α Is Involved in the Transcriptional Regulation of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Gene
por: Zhao, Li-Feng, et al.
Publicado: (2012)

Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia
por: Ellis, R., et al.
Publicado: (2019)

Expression of Alternative Splice Variants of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase-4 in Normoxic and Hypoxic Melanoma Cells
por: Trojan, Sonia E., et al.
Publicado: (2021)

The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
por: Simmen, Frank A, et al.
Publicado: (2008)

Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis
por: Ybañez, Weand S., et al.
Publicado: (2023)

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and “cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats
por: Gao, Liansheng, et al.
Publicado: (2020)

Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
por: Yang, Qiuhua, et al.
Publicado: (2023)

Krüppel-like factor 6 (KLF6) promotes cell proliferation in skeletal myoblasts in response to TGFβ/Smad3 signaling
por: Dionyssiou, Mathew G, et al.
Publicado: (2013)

PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb
por: Ryan, Terence E., et al.
Publicado: (2020)

Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma
por: Yang, Kaiying, et al.
Publicado: (2023)

Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation123
por: Fang, Jiahua, et al.
Publicado: (2016)

Evolution of Allosteric Citrate Binding Sites on 6-phosphofructo-1-kinase
por: Usenik, Aleksandra, et al.
Publicado: (2010)

Lovastatin induced Kruppel like factor 2 (KLF2), Kruppel like factor 6 (KLF6) and Ras homolog family member B (RHOB) genes and preferentially led to viability reduction of Cisplatin-resistant cells
por: Koi, Chiho, et al.
Publicado: (2017)

Involvement of PFKFB3 in Pulmonary Arterial Hypertension Pathogenesis. Is It All about Glycolysis?
por: Bonnet, Sebastien, et al.
Publicado: (2019)

Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis
por: Chen, Weimou, et al.
Publicado: (2021)

The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition
por: Emini Veseli, Besa, et al.
Publicado: (2021)

Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma
por: Li, Jun, et al.
Publicado: (2022)

Mir‐488 alleviates chemoresistance and glycolysis of colorectal cancer by targeting PFKFB3
por: Deng, Xiaojing, et al.
Publicado: (2020)

PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis
por: Yang, Qiuhua, et al.
Publicado: (2023)

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
por: Knights, Alexander J., et al.
Publicado: (2020)

Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein
por: Cullen, Kirsty S., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ft6d8h8telmr1iu1jku09f8sv8