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Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased

Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlati...

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Autores principales: Yang, Hai-Tao, Xiu, Wen-Juan, Liu, Jing-Kun, Yang, Yi, Hou, Xian-Geng, Zheng, Ying-Ying, Wu, Ting-Ting, Wu, Chen-Xin, Xie, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806635/
https://www.ncbi.nlm.nih.gov/pubmed/34590550
http://dx.doi.org/10.1080/21655979.2021.1976897
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author Yang, Hai-Tao
Xiu, Wen-Juan
Liu, Jing-Kun
Yang, Yi
Hou, Xian-Geng
Zheng, Ying-Ying
Wu, Ting-Ting
Wu, Chen-Xin
Xie, Xiang
author_facet Yang, Hai-Tao
Xiu, Wen-Juan
Liu, Jing-Kun
Yang, Yi
Hou, Xian-Geng
Zheng, Ying-Ying
Wu, Ting-Ting
Wu, Chen-Xin
Xie, Xiang
author_sort Yang, Hai-Tao
collection PubMed
description Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH.
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spelling pubmed-88066352022-02-02 Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased Yang, Hai-Tao Xiu, Wen-Juan Liu, Jing-Kun Yang, Yi Hou, Xian-Geng Zheng, Ying-Ying Wu, Ting-Ting Wu, Chen-Xin Xie, Xiang Bioengineered Research Paper Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH. Taylor & Francis 2021-09-30 /pmc/articles/PMC8806635/ /pubmed/34590550 http://dx.doi.org/10.1080/21655979.2021.1976897 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Yang, Hai-Tao
Xiu, Wen-Juan
Liu, Jing-Kun
Yang, Yi
Hou, Xian-Geng
Zheng, Ying-Ying
Wu, Ting-Ting
Wu, Chen-Xin
Xie, Xiang
Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased
title Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased
title_full Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased
title_fullStr Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased
title_full_unstemmed Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased
title_short Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased
title_sort gut microbiota characterization in patients with asymptomatic hyperuricemia: probiotics increased
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806635/
https://www.ncbi.nlm.nih.gov/pubmed/34590550
http://dx.doi.org/10.1080/21655979.2021.1976897
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