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Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased
Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlati...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806635/ https://www.ncbi.nlm.nih.gov/pubmed/34590550 http://dx.doi.org/10.1080/21655979.2021.1976897 |
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author | Yang, Hai-Tao Xiu, Wen-Juan Liu, Jing-Kun Yang, Yi Hou, Xian-Geng Zheng, Ying-Ying Wu, Ting-Ting Wu, Chen-Xin Xie, Xiang |
author_facet | Yang, Hai-Tao Xiu, Wen-Juan Liu, Jing-Kun Yang, Yi Hou, Xian-Geng Zheng, Ying-Ying Wu, Ting-Ting Wu, Chen-Xin Xie, Xiang |
author_sort | Yang, Hai-Tao |
collection | PubMed |
description | Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH. |
format | Online Article Text |
id | pubmed-8806635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88066352022-02-02 Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased Yang, Hai-Tao Xiu, Wen-Juan Liu, Jing-Kun Yang, Yi Hou, Xian-Geng Zheng, Ying-Ying Wu, Ting-Ting Wu, Chen-Xin Xie, Xiang Bioengineered Research Paper Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH. Taylor & Francis 2021-09-30 /pmc/articles/PMC8806635/ /pubmed/34590550 http://dx.doi.org/10.1080/21655979.2021.1976897 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Yang, Hai-Tao Xiu, Wen-Juan Liu, Jing-Kun Yang, Yi Hou, Xian-Geng Zheng, Ying-Ying Wu, Ting-Ting Wu, Chen-Xin Xie, Xiang Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased |
title | Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased |
title_full | Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased |
title_fullStr | Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased |
title_full_unstemmed | Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased |
title_short | Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased |
title_sort | gut microbiota characterization in patients with asymptomatic hyperuricemia: probiotics increased |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806635/ https://www.ncbi.nlm.nih.gov/pubmed/34590550 http://dx.doi.org/10.1080/21655979.2021.1976897 |
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