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A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma
Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and has a poor prognosis. Pyroptosis is regulated via the activation of inflammasomes and participates in tumorigenesis. However, the effects of pyroptosis-related lncRNAs (PRlncRNAs) on LUAD have not y...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806662/ https://www.ncbi.nlm.nih.gov/pubmed/34488540 http://dx.doi.org/10.1080/21655979.2021.1972078 |
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author | Song, Jiahang Sun, Yuanyuan Cao, Hui Liu, Zhengcheng Xi, Lei Dong, Changqing Yang, Rusong Shi, Ye |
author_facet | Song, Jiahang Sun, Yuanyuan Cao, Hui Liu, Zhengcheng Xi, Lei Dong, Changqing Yang, Rusong Shi, Ye |
author_sort | Song, Jiahang |
collection | PubMed |
description | Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and has a poor prognosis. Pyroptosis is regulated via the activation of inflammasomes and participates in tumorigenesis. However, the effects of pyroptosis-related lncRNAs (PRlncRNAs) on LUAD have not yet been completely elucidated. Therefore, we attempted to systematically explore patterns of cell pyroptosis to establish a novel signature for predicting LUAD survival. Based on TCGA database, we set up a prognostic model by incorporating PRlncRNAs with differential expression using Cox regression and LASSO regression. Kaplan–Meier analysis was conducted to compare the survival of LUAD patients. We further simplified the risk model and created a nomogram to enhance the prediction of LUAD prognosis. Altogether, 84 PRlncRNAs with differential expression were discovered. Subsequently, a new risk model was constructed based on five PRlncRNAs, GSEC, FAM83A-AS1, AL606489.1, AL034397.3 and AC010980.2. The proposed signature exhibited good performance in prognostic prediction and was related to immunocyte infiltration. The nomogram exactly forecasted the overall survival of patients and had excellent clinical utility. In the present study, the five-lncRNA prognostic risk signature and nomogram are trustworthy and effective indicators for predicting the prognosis of LUAD. |
format | Online Article Text |
id | pubmed-8806662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88066622022-02-02 A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma Song, Jiahang Sun, Yuanyuan Cao, Hui Liu, Zhengcheng Xi, Lei Dong, Changqing Yang, Rusong Shi, Ye Bioengineered Research Paper Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and has a poor prognosis. Pyroptosis is regulated via the activation of inflammasomes and participates in tumorigenesis. However, the effects of pyroptosis-related lncRNAs (PRlncRNAs) on LUAD have not yet been completely elucidated. Therefore, we attempted to systematically explore patterns of cell pyroptosis to establish a novel signature for predicting LUAD survival. Based on TCGA database, we set up a prognostic model by incorporating PRlncRNAs with differential expression using Cox regression and LASSO regression. Kaplan–Meier analysis was conducted to compare the survival of LUAD patients. We further simplified the risk model and created a nomogram to enhance the prediction of LUAD prognosis. Altogether, 84 PRlncRNAs with differential expression were discovered. Subsequently, a new risk model was constructed based on five PRlncRNAs, GSEC, FAM83A-AS1, AL606489.1, AL034397.3 and AC010980.2. The proposed signature exhibited good performance in prognostic prediction and was related to immunocyte infiltration. The nomogram exactly forecasted the overall survival of patients and had excellent clinical utility. In the present study, the five-lncRNA prognostic risk signature and nomogram are trustworthy and effective indicators for predicting the prognosis of LUAD. Taylor & Francis 2021-09-07 /pmc/articles/PMC8806662/ /pubmed/34488540 http://dx.doi.org/10.1080/21655979.2021.1972078 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Song, Jiahang Sun, Yuanyuan Cao, Hui Liu, Zhengcheng Xi, Lei Dong, Changqing Yang, Rusong Shi, Ye A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma |
title | A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma |
title_full | A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma |
title_fullStr | A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma |
title_full_unstemmed | A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma |
title_short | A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma |
title_sort | novel pyroptosis-related lncrna signature for prognostic prediction in patients with lung adenocarcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806662/ https://www.ncbi.nlm.nih.gov/pubmed/34488540 http://dx.doi.org/10.1080/21655979.2021.1972078 |
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