Coordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease

In the present study, mitral valve tissues from three mitral stenosis patients with RHD by valve replacement and two healthy donors were harvested and conducted DNA methylation signature on PRKCA by MeDIP-qPCR. The presence of hypomethylated CpG islands at promoter and 5ʹ terminal of PRKCA was obser...

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Detalles Bibliográficos
Autores principales: Xie, Zan, Wang, Qianli, Hu, Shaojuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806685/
https://www.ncbi.nlm.nih.gov/pubmed/34482802
http://dx.doi.org/10.1080/21655979.2021.1971482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806685/
https://www.ncbi.nlm.nih.gov/pubmed/34482802
http://dx.doi.org/10.1080/21655979.2021.1971482

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