Cargando…

The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients

N6-methyladenosine (m6A) methylation participates in the progression of bladder cancer (BCa). Nevertheless, the regulatory mechanism of alpha-ketoglutarate-dependent dioxygenase FTO influencing the BCa progression has still remained elusive. In this study, to investigate the tumor-suppressive effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yi, Wenfa, Yu, Yong, Li, Yafei, Yang, Juan, Gao, Shuying, Xu, Lingfen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806820/ https://www.ncbi.nlm.nih.gov/pubmed/34499008 http://dx.doi.org/10.1080/21655979.2021.1964893

Ejemplares similares

Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis
por: Lamichhane, Pratik, et al.
Publicado: (2023)

Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R)
por: Li, Sheng, et al.
Publicado: (2022)

Linkage disequilibrium block single-nucleotide polymorphisms in FTO alpha ketoglutarate dependent dioxygenase gene inference with breast cancer and Type II diabetes in Pakistani female population
por: Mansoor, Qaisar, et al.
Publicado: (2023)

Cofactor Generation Cascade for α-Ketoglutarate and Fe(II)-Dependent Dioxygenases
por: Busch, Florian, et al.
Publicado: (2020)

Calmodulin as Ca(2+)-Dependent Interactor of FTO Dioxygenase
por: Marcinkowski, Michał, et al.
Publicado: (2021)

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2
por: Lin, An-Ping, et al.
Publicado: (2015)

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
por: Zhao, Xu, et al.
Publicado: (2014)

Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
por: Zheng, Qing-Kang, et al.
Publicado: (2021)

Nitric oxide inhibits FTO demethylase activity to regulate N(6)-methyladenosine mRNA methylation
por: Kuschman, Hannah Petraitis, et al.
Publicado: (2023)

Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
por: Evans, Brad, et al.
Publicado: (2015)

DNA Demethylation in the Processes of Repair and Epigenetic Regulation Performed by 2-Ketoglutarate-Dependent DNA Dioxygenases
por: Kuznetsov, Nikita A., et al.
Publicado: (2021)

N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO‐PGC‐1α signalling axis
por: Zhuang, Changshui, et al.
Publicado: (2019)

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner
por: Huang, Jiapeng, et al.
Publicado: (2022)

AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N(6)-methyladenosine
por: Wu, Weiche, et al.
Publicado: (2017)

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N(6)-methyladenosine demethylase activity in cells
por: Cheong, Adeline, et al.
Publicado: (2018)

N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
por: Zou, Libin, et al.
Publicado: (2022)

N(6)-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO
por: Jia, Guifang, et al.
Publicado: (2011)

Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner
por: Wu, Yifei, et al.
Publicado: (2023)

A novel inhibitor of N(6)-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities
por: Xie, Guoyou, et al.
Publicado: (2022)

Current Advances in N6-Methyladenosine Methylation Modification During Bladder Cancer
por: Liu, Qiang
Publicado: (2022)

N(6)-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury
por: Xu, Kaiwei, et al.
Publicado: (2020)

Alpha-Ketoglutarate: Physiological Functions and Applications
por: Wu, Nan, et al.
Publicado: (2016)

Alpha-ketoglutarate for adipose tissue rejuvenation
por: Tian, Qiyu, et al.
Publicado: (2020)

N(6)-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1
por: Wang, Duo, et al.
Publicado: (2021)

Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
por: Wang, Yuan, et al.
Publicado: (2020)

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker
por: Zhao, Chengwen, et al.
Publicado: (2021)

Putative mitochondrial α-ketoglutarate-dependent dioxygenase Fmp12 controls utilization of proline as an energy source in Saccharomyces cerevisiae
por: Nishida, Ikuhisa, et al.
Publicado: (2016)

The Antioxidative Function of Alpha-Ketoglutarate and Its Applications
por: Liu, Shaojuan, et al.
Publicado: (2018)

Electrostatic Perturbations in the Substrate‐Binding Pocket of Taurine/α‐Ketoglutarate Dioxygenase Determine its Selectivity
por: Ali, Hafiz Saqib, et al.
Publicado: (2022)

N6-methyladenosine methylation in kidney injury
por: Wang, Qimeng, et al.
Publicado: (2023)

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
por: Zou, Shui, et al.
Publicado: (2016)

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
por: Niu, Yi, et al.
Publicado: (2019)

Metabolite alpha-ketoglutarate: a novel target of gasdermin C-dependent pyroptosis
por: Zhang, Yao, et al.
Publicado: (2023)

A Single-Turnover Kinetic Study of DNA Demethylation Catalyzed by Fe(II)/α-Ketoglutarate-Dependent Dioxygenase AlkB
por: Kanazhevskaya, Lyubov Yu., et al.
Publicado: (2019)

2-Ketoglutarate-Generated In Vitro Enzymatic Biosystem Facilitates Fe(II)/2-Ketoglutarate-Dependent Dioxygenase-Mediated C–H Bond Oxidation for (2s,3r,4s)-4-Hydroxyisoleucine Synthesis
por: Jing, Xiao-Ran, et al.
Publicado: (2020)

LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2
por: Wang, Fan, et al.
Publicado: (2023)

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
por: Bartosovic, Marek, et al.
Publicado: (2017)

A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis
por: Eng, Jasmine Ga May, et al.
Publicado: (2022)

N6-Methyladenosine RNA Methylation in Cardiovascular Diseases
por: Liu, Chi, et al.
Publicado: (2022)

Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine
por: Xu, Yating, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7m7899vpkvaccisi18ummlg73m