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Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer
Chemokines are a type of cytokine that participate in the migration of macrophages and monocytes to inflammatory cells. In particular, CXC chemokines are involved in the development of many cancers. Evidence for the association between interleukin-8 receptor B (IL8RB) rs1126579 C > T variation an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806877/ https://www.ncbi.nlm.nih.gov/pubmed/34238119 http://dx.doi.org/10.1080/21655979.2021.1947442 |
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author | Zhu, Lihong Tang, Bowen Zhang, Ze Wei, Shuzhang Lv, Zhiwei Zhang, Yujuan Yang, Minlie |
author_facet | Zhu, Lihong Tang, Bowen Zhang, Ze Wei, Shuzhang Lv, Zhiwei Zhang, Yujuan Yang, Minlie |
author_sort | Zhu, Lihong |
collection | PubMed |
description | Chemokines are a type of cytokine that participate in the migration of macrophages and monocytes to inflammatory cells. In particular, CXC chemokines are involved in the development of many cancers. Evidence for the association between interleukin-8 receptor B (IL8RB) rs1126579 C > T variation and cancer risk remains contradictory. Here, we utilized a comprehensive analysis containing odds ratios (ORs), regression, and in silico tools to evaluate the effect of IL8RB polymorphism on cancer risk. We further employed Gene set enrichment analysis combined with ELISA to evaluate the IL8RB expression in patients with prostate cancer (PRAD). A total of 5,187 cancer cases and 6,691 controls were included in the present analysis. Individuals with the TT genotype were associated with an increased risk of cancer compared to those with the TC+CC genotype. In a subgroup analysis by type of cancer, individuals with the TT genotype had a 39% increased risk of urinary cancer compared to those with the CC genotype. A subgroup analysis by ethnicity showed that Asians carrying the TC genotype had a 26% lower risk of cancer than those carrying the CC genotype. We found that the expression of IL8RB was down-regulated in PRAD. Compared to that in PRAD subjects carrying the CC genotype, the expression of IL8RB was decreased in patients with the TT+TC genotype. In conclusion, the IL8RB rs1126579 C > T variation may be associated with cancer risk, especially in Asian populations and patients with PRAD. |
format | Online Article Text |
id | pubmed-8806877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88068772022-02-02 Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer Zhu, Lihong Tang, Bowen Zhang, Ze Wei, Shuzhang Lv, Zhiwei Zhang, Yujuan Yang, Minlie Bioengineered Research Paper Chemokines are a type of cytokine that participate in the migration of macrophages and monocytes to inflammatory cells. In particular, CXC chemokines are involved in the development of many cancers. Evidence for the association between interleukin-8 receptor B (IL8RB) rs1126579 C > T variation and cancer risk remains contradictory. Here, we utilized a comprehensive analysis containing odds ratios (ORs), regression, and in silico tools to evaluate the effect of IL8RB polymorphism on cancer risk. We further employed Gene set enrichment analysis combined with ELISA to evaluate the IL8RB expression in patients with prostate cancer (PRAD). A total of 5,187 cancer cases and 6,691 controls were included in the present analysis. Individuals with the TT genotype were associated with an increased risk of cancer compared to those with the TC+CC genotype. In a subgroup analysis by type of cancer, individuals with the TT genotype had a 39% increased risk of urinary cancer compared to those with the CC genotype. A subgroup analysis by ethnicity showed that Asians carrying the TC genotype had a 26% lower risk of cancer than those carrying the CC genotype. We found that the expression of IL8RB was down-regulated in PRAD. Compared to that in PRAD subjects carrying the CC genotype, the expression of IL8RB was decreased in patients with the TT+TC genotype. In conclusion, the IL8RB rs1126579 C > T variation may be associated with cancer risk, especially in Asian populations and patients with PRAD. Taylor & Francis 2021-07-08 /pmc/articles/PMC8806877/ /pubmed/34238119 http://dx.doi.org/10.1080/21655979.2021.1947442 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Zhu, Lihong Tang, Bowen Zhang, Ze Wei, Shuzhang Lv, Zhiwei Zhang, Yujuan Yang, Minlie Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer |
title | Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer |
title_full | Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer |
title_fullStr | Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer |
title_full_unstemmed | Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer |
title_short | Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer |
title_sort | effect of interleukin-8 receptor b (il8rb) rs1126579 c>t variation on the risk to cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806877/ https://www.ncbi.nlm.nih.gov/pubmed/34238119 http://dx.doi.org/10.1080/21655979.2021.1947442 |
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