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The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma
Glioblastoma is a malignant intracranial tumor with indispensable growth. Identification of biomarkers associated with the progression of tumors could benefit the clinical therapy of and improve patient’s survival. miR-411 has been reported to play a role in other cancers, while its function in glio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806974/ https://www.ncbi.nlm.nih.gov/pubmed/34606414 http://dx.doi.org/10.1080/21655979.2021.1988365 |
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author | Fan, Weihua Yu, Xia Li, Kunrong Zhu, Mingtao |
author_facet | Fan, Weihua Yu, Xia Li, Kunrong Zhu, Mingtao |
author_sort | Fan, Weihua |
collection | PubMed |
description | Glioblastoma is a malignant intracranial tumor with indispensable growth. Identification of biomarkers associated with the progression of tumors could benefit the clinical therapy of and improve patient’s survival. miR-411 has been reported to play a role in other cancers, while its function in glioblastoma has been explored in the present study. The expression of miR-411 was evaluated in glioblastoma tissues (collected from 108 glioblastoma patients) and cells by polymerase chain reaction. The clinical significance of miR-411 was estimated with a series of statistical analyses. The biological function of miR-411 in the cellular processes of glioblastoma was assessed by cell counting kit 8 and Transwell assay. The expression of miR-411 was significantly reduced in glioblastoma, which was associated with the Karnofsky Performance Score (KPS) and Isocitrate dehydrogenase 1 (IDH1) status of patients. miR-411 was identified as an independent prognostic indicator that correlated with the poor prognosis of patients. miR-411 suppressed the growth, migration, and invasion of glioblastoma cells via modulating signal transducer and activator of transcription 3 (STAT3). miR-411 participated in the development of glioblastoma and function as a prognostic biomarker. miR-411 functions as a tumor suppressor, which provides a novel potential therapeutic target for glioblastoma. |
format | Online Article Text |
id | pubmed-8806974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88069742022-02-02 The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma Fan, Weihua Yu, Xia Li, Kunrong Zhu, Mingtao Bioengineered Research Paper Glioblastoma is a malignant intracranial tumor with indispensable growth. Identification of biomarkers associated with the progression of tumors could benefit the clinical therapy of and improve patient’s survival. miR-411 has been reported to play a role in other cancers, while its function in glioblastoma has been explored in the present study. The expression of miR-411 was evaluated in glioblastoma tissues (collected from 108 glioblastoma patients) and cells by polymerase chain reaction. The clinical significance of miR-411 was estimated with a series of statistical analyses. The biological function of miR-411 in the cellular processes of glioblastoma was assessed by cell counting kit 8 and Transwell assay. The expression of miR-411 was significantly reduced in glioblastoma, which was associated with the Karnofsky Performance Score (KPS) and Isocitrate dehydrogenase 1 (IDH1) status of patients. miR-411 was identified as an independent prognostic indicator that correlated with the poor prognosis of patients. miR-411 suppressed the growth, migration, and invasion of glioblastoma cells via modulating signal transducer and activator of transcription 3 (STAT3). miR-411 participated in the development of glioblastoma and function as a prognostic biomarker. miR-411 functions as a tumor suppressor, which provides a novel potential therapeutic target for glioblastoma. Taylor & Francis 2021-10-18 /pmc/articles/PMC8806974/ /pubmed/34606414 http://dx.doi.org/10.1080/21655979.2021.1988365 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Fan, Weihua Yu, Xia Li, Kunrong Zhu, Mingtao The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma |
title | The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma |
title_full | The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma |
title_fullStr | The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma |
title_full_unstemmed | The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma |
title_short | The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma |
title_sort | alerting expression of microrna-411 predicts clinical prognosis and regulates tumor progression of glioblastoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806974/ https://www.ncbi.nlm.nih.gov/pubmed/34606414 http://dx.doi.org/10.1080/21655979.2021.1988365 |
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