Cargando…
Alterations of oral microbiota in patients with panic disorder
The main characteristics of panic disorder (PD) include recurrent panic attacks and persistent worry, accompanied by other physical and cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety and depression, little is known about the relationship be...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806997/ https://www.ncbi.nlm.nih.gov/pubmed/34666612 http://dx.doi.org/10.1080/21655979.2021.1994738 |
_version_ | 1784643592818524160 |
---|---|
author | Xie, Zunli Jiang, Weiqing Deng, Mingzhu Wang, Wei Xie, Xian Feng, Xia Shi, Yinping Zhang, Xueyan Song, Dong Yuan, Ziyu Wang, Yonggang |
author_facet | Xie, Zunli Jiang, Weiqing Deng, Mingzhu Wang, Wei Xie, Xian Feng, Xia Shi, Yinping Zhang, Xueyan Song, Dong Yuan, Ziyu Wang, Yonggang |
author_sort | Xie, Zunli |
collection | PubMed |
description | The main characteristics of panic disorder (PD) include recurrent panic attacks and persistent worry, accompanied by other physical and cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety and depression, little is known about the relationship between oral microbiota and PD. Therefore, the objective of this study was to explore a possible correlation between oral microbiota and PD. We conducted 16S rRNA sequencing to compare differences in the oral microbiota of patients with PD (n = 26) and healthy controls (n = 40). Patients with PD exhibited higher alpha diversity (abundance and evenness) in their oral microbiota than healthy controls, while analysis of beta diversity revealed that the two groups differed in microbial community composition. Moreover, the relative abundance of 61 genera differed between them. Overall, PD resulted in distinct oral microbial profiles that could be potential diagnostic markers and therapeutic targets. |
format | Online Article Text |
id | pubmed-8806997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88069972022-02-02 Alterations of oral microbiota in patients with panic disorder Xie, Zunli Jiang, Weiqing Deng, Mingzhu Wang, Wei Xie, Xian Feng, Xia Shi, Yinping Zhang, Xueyan Song, Dong Yuan, Ziyu Wang, Yonggang Bioengineered Research Paper The main characteristics of panic disorder (PD) include recurrent panic attacks and persistent worry, accompanied by other physical and cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety and depression, little is known about the relationship between oral microbiota and PD. Therefore, the objective of this study was to explore a possible correlation between oral microbiota and PD. We conducted 16S rRNA sequencing to compare differences in the oral microbiota of patients with PD (n = 26) and healthy controls (n = 40). Patients with PD exhibited higher alpha diversity (abundance and evenness) in their oral microbiota than healthy controls, while analysis of beta diversity revealed that the two groups differed in microbial community composition. Moreover, the relative abundance of 61 genera differed between them. Overall, PD resulted in distinct oral microbial profiles that could be potential diagnostic markers and therapeutic targets. Taylor & Francis 2021-10-26 /pmc/articles/PMC8806997/ /pubmed/34666612 http://dx.doi.org/10.1080/21655979.2021.1994738 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Xie, Zunli Jiang, Weiqing Deng, Mingzhu Wang, Wei Xie, Xian Feng, Xia Shi, Yinping Zhang, Xueyan Song, Dong Yuan, Ziyu Wang, Yonggang Alterations of oral microbiota in patients with panic disorder |
title | Alterations of oral microbiota in patients with panic disorder |
title_full | Alterations of oral microbiota in patients with panic disorder |
title_fullStr | Alterations of oral microbiota in patients with panic disorder |
title_full_unstemmed | Alterations of oral microbiota in patients with panic disorder |
title_short | Alterations of oral microbiota in patients with panic disorder |
title_sort | alterations of oral microbiota in patients with panic disorder |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806997/ https://www.ncbi.nlm.nih.gov/pubmed/34666612 http://dx.doi.org/10.1080/21655979.2021.1994738 |
work_keys_str_mv | AT xiezunli alterationsoforalmicrobiotainpatientswithpanicdisorder AT jiangweiqing alterationsoforalmicrobiotainpatientswithpanicdisorder AT dengmingzhu alterationsoforalmicrobiotainpatientswithpanicdisorder AT wangwei alterationsoforalmicrobiotainpatientswithpanicdisorder AT xiexian alterationsoforalmicrobiotainpatientswithpanicdisorder AT fengxia alterationsoforalmicrobiotainpatientswithpanicdisorder AT shiyinping alterationsoforalmicrobiotainpatientswithpanicdisorder AT zhangxueyan alterationsoforalmicrobiotainpatientswithpanicdisorder AT songdong alterationsoforalmicrobiotainpatientswithpanicdisorder AT yuanziyu alterationsoforalmicrobiotainpatientswithpanicdisorder AT wangyonggang alterationsoforalmicrobiotainpatientswithpanicdisorder |