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New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration
Distinctive characteristics of articular cartilage such as avascularity and low chondrocyte conversion rate present numerous challenges for orthopedists. Tissue engineering is a novel approach that ameliorates the regeneration process by exploiting the potential of cells, biodegradable materials, an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807044/ https://www.ncbi.nlm.nih.gov/pubmed/35118158 http://dx.doi.org/10.1155/2022/7638245 |
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author | Jelodari, Sahar Ebrahimi Sadrabadi, Amin Zarei, Fatemeh Jahangir, Shahrbanoo Azami, Mahmoud Sheykhhasan, Mohsen Hosseini, Samaneh |
author_facet | Jelodari, Sahar Ebrahimi Sadrabadi, Amin Zarei, Fatemeh Jahangir, Shahrbanoo Azami, Mahmoud Sheykhhasan, Mohsen Hosseini, Samaneh |
author_sort | Jelodari, Sahar |
collection | PubMed |
description | Distinctive characteristics of articular cartilage such as avascularity and low chondrocyte conversion rate present numerous challenges for orthopedists. Tissue engineering is a novel approach that ameliorates the regeneration process by exploiting the potential of cells, biodegradable materials, and growth factors. However, problems exist with the use of tissue-engineered construct, the most important of which is scaffold-cartilage integration. Recently, many attempts have been made to address this challenge via manipulation of cellular, material, and biomolecular composition of engineered tissue. Hence, in this review, we highlight strategies that facilitate cartilage-scaffold integration. Recent advances in where efficient integration between a scaffold and native cartilage could be achieved are emphasized, in addition to the positive aspects and remaining problems that will drive future research. |
format | Online Article Text |
id | pubmed-8807044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88070442022-02-02 New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration Jelodari, Sahar Ebrahimi Sadrabadi, Amin Zarei, Fatemeh Jahangir, Shahrbanoo Azami, Mahmoud Sheykhhasan, Mohsen Hosseini, Samaneh Biomed Res Int Review Article Distinctive characteristics of articular cartilage such as avascularity and low chondrocyte conversion rate present numerous challenges for orthopedists. Tissue engineering is a novel approach that ameliorates the regeneration process by exploiting the potential of cells, biodegradable materials, and growth factors. However, problems exist with the use of tissue-engineered construct, the most important of which is scaffold-cartilage integration. Recently, many attempts have been made to address this challenge via manipulation of cellular, material, and biomolecular composition of engineered tissue. Hence, in this review, we highlight strategies that facilitate cartilage-scaffold integration. Recent advances in where efficient integration between a scaffold and native cartilage could be achieved are emphasized, in addition to the positive aspects and remaining problems that will drive future research. Hindawi 2022-01-25 /pmc/articles/PMC8807044/ /pubmed/35118158 http://dx.doi.org/10.1155/2022/7638245 Text en Copyright © 2022 Sahar Jelodari et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jelodari, Sahar Ebrahimi Sadrabadi, Amin Zarei, Fatemeh Jahangir, Shahrbanoo Azami, Mahmoud Sheykhhasan, Mohsen Hosseini, Samaneh New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration |
title | New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration |
title_full | New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration |
title_fullStr | New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration |
title_full_unstemmed | New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration |
title_short | New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration |
title_sort | new insights into cartilage tissue engineering: improvement of tissue-scaffold integration to enhance cartilage regeneration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807044/ https://www.ncbi.nlm.nih.gov/pubmed/35118158 http://dx.doi.org/10.1155/2022/7638245 |
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