Combined targeting of EGFR and BRAF triggers regression of osimertinib resistance by using osimertinib and vemurafenib concurrently in a patient with heterogeneity between different lesions

Acquired BRAF V600E mutation can occur in tumors with EGFR mutation and is suspected as a resistance mechanism to third‐generation EGFR‐tyrosine kinase inhibitors (TKIs). However, the treatment strategy for the coexistence of EGFR and acquired BRAF mutation with heterogeneity in lung cancer has not...

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Detalles Bibliográficos
Autores principales: Sun, Mengyao, Wang, Xu, Xu, Yinghui, Sun, Chao, Guo, Ye, Qiu, Shi, Zhao, Renshan, Zhu, Wenhao, Ma, Kewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807254/
https://www.ncbi.nlm.nih.gov/pubmed/34962076
http://dx.doi.org/10.1111/1759-7714.14295

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