Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons

While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination “breakthrough” COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, re...

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Detalles Bibliográficos
Autores principales: Liu, Jamin, Laurie, Matthew T, Rubio, Luis, Vazquez, Sara E, Sunshine, Sara, Mitchell, Anthea M, Hapte-Selassie, Matthias, Mann, Sabrina A, Pilarowski, Genay, Black, Douglas, Marquez, Carina, Rojas, Susana, Lionakis, Michail S, Petersen, Maya, Whitman, Jeffrey D, Jain, Vivek, Anderson, Mark, Havlir, Diane, DeRisi, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807302/
https://www.ncbi.nlm.nih.gov/pubmed/35037050
http://dx.doi.org/10.1093/cid/ciac029
Descripción
Sumario:While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination “breakthrough” COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.

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