Cargando…

Reciprocal epigenetic remodeling controls testicular cancer hypersensitivity to hypomethylating agents and chemotherapy

Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin hypersensitivity and resistance in TGCTs remain poo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Ratnakar, Fazal, Zeeshan, Bikorimana, Emmanuel, Boyd, Raya I., Yerby, Cliff, Tomlin, Megan, Baldwin, Hannah, Shokry, Doha, Corbet, Andrea K., Shahid, Khadeeja, Hattab, Aleyah, Freemantle, Sarah J., Spinella, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807365/ https://www.ncbi.nlm.nih.gov/pubmed/34482638 http://dx.doi.org/10.1002/1878-0261.13096

Ejemplares similares

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors
por: Singh, Ratnakar, et al.
Publicado: (2019)

G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells
por: Corbet, Andrea K., et al.
Publicado: (2023)

Mechanisms of cisplatin sensitivity and resistance in testicular germ cell tumors
por: Singh, Ratnakar, et al.
Publicado: (2019)

Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell Tumors
por: Singh, Ratnakar, et al.
Publicado: (2021)

Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer
por: Boyd, Raya I., et al.
Publicado: (2022)

Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factors
por: Wen, Yi, et al.
Publicado: (2022)

A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer
por: Albany, Costantine, et al.
Publicado: (2020)

Transformations between rotational and translational invariants formulated in reciprocal spaces
por: Baldwin, Philip R.
Publicado: (2023)

Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration
por: Luo, Yang, et al.
Publicado: (2021)

Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation
por: Biswal, Bijesh K., et al.
Publicado: (2012)

IRX1 hypomethylation in osteosarcoma metastasis
por: Lu, Jinchang, et al.
Publicado: (2015)

Consistent DNA Hypomethylations in Prostate Cancer
por: Araúzo-Bravo, Marcos J., et al.
Publicado: (2022)

p53 Hypersensitivity Is the Predominant Mechanism of the Unique Responsiveness of Testicular Germ Cell Tumor (TGCT) Cells to Cisplatin
por: Gutekunst, Matthias, et al.
Publicado: (2011)

Direct Reciprocity in Spatial Populations Enhances R-Reciprocity As Well As ST-Reciprocity
por: Miyaji, Kohei, et al.
Publicado: (2013)

Comparison of Hypomethylator Monotherapy with Hypomethylator plus Chemotherapy for Intermediate/High-Risk MDS or AML: A Meta-Analysis
por: Ji, Jiang, et al.
Publicado: (2020)

The reciprocal relationship between openness and creativity: from neurobiology to multicultural environments
por: Abu Raya, Maison, et al.
Publicado: (2023)

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine
por: Albany, Costantine, et al.
Publicado: (2016)

Reciprocity
Publicado: (1899)

Reciprocity
Publicado: (1898)

Reciprocity
por: O’Shea, Jesse
Publicado: (2019)

The robustness of reciprocity: Experimental evidence that each form of reciprocity is robust to the presence of other forms of reciprocity
por: Melamed, David, et al.
Publicado: (2020)

Spinal 5-HT(3) receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade
por: Guo, Wei, et al.
Publicado: (2014)

LINE-1 hypomethylation in familial and sporadic cancer
por: Pavicic, Walter, et al.
Publicado: (2012)

Naïve pluripotency is associated with global DNA hypomethylation
por: Leitch, Harry G., et al.
Publicado: (2013)

LINE-1 and Alu hypomethylation in mucoepidermoid carcinoma
por: Sirivanichsuntorn, Porntipa, et al.
Publicado: (2013)

Analyses of Hypomethylated Oil Palm Gene Space
por: Low, Eng-Ti L., et al.
Publicado: (2014)

Clinical Results of Hypomethylating Agents in AML Treatment
por: Cruijsen, Marjan, et al.
Publicado: (2014)

Hypomethylation Causes MIR21 Overexpression in Tumors
por: Lu, Jun, et al.
Publicado: (2020)

The association between Alu hypomethylation and the severity of hypertension
por: Thongsroy, Jirapan, et al.
Publicado: (2022)

The genome-wide mutational consequences of DNA hypomethylation
por: Besselink, Nicolle, et al.
Publicado: (2023)

La risa del diablo : novela
por: Yerby, Frank, 1916-1991
Publicado: (1974)

Negros son los dioses de mi África
por: Yerby, Frank, 1916-1991

La hoja sarracena
por: Yerby, Frank, 1916-1991

Color doppler ultrasound for diagnosis of testicular carcinoma: A comparison with gold standard histopathology
por: Fazal, Kamran, et al.
Publicado: (2022)

Reciprocity in elastodynamics
por: Achenbach, J D
Publicado: (2003)

Reciprocity in Medicine
Publicado: (1897)

Reciprocity in Licensure
Publicado: (1905)

Medical Reciprocity
Publicado: (1899)

Interstate Reciprocity
Publicado: (1903)

Medical Reciprocity
Publicado: (1903)

Cannot write session to /tmp/vufind_sessions/sess_cidabat4kminkndv3tk25ad391