The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor

Wilms tumour (WT), an embryonal kidney cancer, has been extensively characterised for genetic and epigenetic alterations, but a proportion of WTs still lack identifiable abnormalities. To uncover DNA methylation changes critical for WT pathogenesis, we compared the epigenome of foetal kidney with tw...

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Detalles Bibliográficos
Autores principales: Legge, Danny, Li, Ling, Moriarty, Whei, Lee, David, Szemes, Marianna, Zahed, Asef, Panousopoulos, Leonidas, Chung, Wan Yun, Aghabi, Yara, Barratt, Jasmin, Williams, Richard, Pritchard‐Jones, Kathy, Malik, Karim T.A., Oltean, Sebastian, Brown, Keith W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807366/
https://www.ncbi.nlm.nih.gov/pubmed/34520622
http://dx.doi.org/10.1002/1878-0261.13101

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