The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

Ubiquitin-specific peptidase 15 (USP15) is a deubiquitinating enzyme implicated in critical cellular and oncogenic processes. We report that USP15 mRNA and protein are overexpressed in human acute myeloid leukemia (AML) as compared to normal hematopoietic progenitor cells. This high expression of US...

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Detalles Bibliográficos
Autores principales: Niederkorn, Madeline, Ishikawa, Chiharu, M. Hueneman, Kathleen, Bartram, James, Stepanchick, Emily, R. Bennett, Joshua, E. Culver-Cochran, Ashley, Bolanos, Lyndsey C., Uible, Emma, Choi, Kwangmin, Wunderlich, Mark, Perentesis, John P., M. Chlon, Timothy, Filippi, Marie-Dominique, Starczynowski, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807387/
https://www.ncbi.nlm.nih.gov/pubmed/34465865
http://dx.doi.org/10.1038/s41375-021-01394-z

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