ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis

ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participat...

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Detalles Bibliográficos
Autores principales: Jakobczyk, Hélène, Jiang, Yan, Debaize, Lydie, Soubise, Benoit, Avner, Stéphane, Sérandour, Aurélien A., Rouger-Gaudichon, Jérémie, Rio, Anne-Gaëlle, Carroll, Jason S., Raslova, Hana, Gilot, David, Liu, Ziling, Demengeot, Jocelyne, Salbert, Gilles, Douet-Guilbert, Nathalie, Corcos, Laurent, Galibert, Marie-Dominique, Gandemer, Virginie, Troadec, Marie-Bérengère
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807389/
https://www.ncbi.nlm.nih.gov/pubmed/34535762
http://dx.doi.org/10.1038/s41375-021-01409-9
Descripción
Sumario:ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of RAG1 expression.

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