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ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis
ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participat...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807389/ https://www.ncbi.nlm.nih.gov/pubmed/34535762 http://dx.doi.org/10.1038/s41375-021-01409-9 |
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| author | Jakobczyk, Hélène Jiang, Yan Debaize, Lydie Soubise, Benoit Avner, Stéphane Sérandour, Aurélien A. Rouger-Gaudichon, Jérémie Rio, Anne-Gaëlle Carroll, Jason S. Raslova, Hana Gilot, David Liu, Ziling Demengeot, Jocelyne Salbert, Gilles Douet-Guilbert, Nathalie Corcos, Laurent Galibert, Marie-Dominique Gandemer, Virginie Troadec, Marie-Bérengère |
| author_facet | Jakobczyk, Hélène Jiang, Yan Debaize, Lydie Soubise, Benoit Avner, Stéphane Sérandour, Aurélien A. Rouger-Gaudichon, Jérémie Rio, Anne-Gaëlle Carroll, Jason S. Raslova, Hana Gilot, David Liu, Ziling Demengeot, Jocelyne Salbert, Gilles Douet-Guilbert, Nathalie Corcos, Laurent Galibert, Marie-Dominique Gandemer, Virginie Troadec, Marie-Bérengère |
| author_sort | Jakobczyk, Hélène |
| collection | PubMed |
| description | ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of RAG1 expression. |
| format | Online Article Text |
| id | pubmed-8807389 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-88073892022-02-07 ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis Jakobczyk, Hélène Jiang, Yan Debaize, Lydie Soubise, Benoit Avner, Stéphane Sérandour, Aurélien A. Rouger-Gaudichon, Jérémie Rio, Anne-Gaëlle Carroll, Jason S. Raslova, Hana Gilot, David Liu, Ziling Demengeot, Jocelyne Salbert, Gilles Douet-Guilbert, Nathalie Corcos, Laurent Galibert, Marie-Dominique Gandemer, Virginie Troadec, Marie-Bérengère Leukemia Letter ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of RAG1 expression. Nature Publishing Group UK 2021-09-17 2022 /pmc/articles/PMC8807389/ /pubmed/34535762 http://dx.doi.org/10.1038/s41375-021-01409-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Letter Jakobczyk, Hélène Jiang, Yan Debaize, Lydie Soubise, Benoit Avner, Stéphane Sérandour, Aurélien A. Rouger-Gaudichon, Jérémie Rio, Anne-Gaëlle Carroll, Jason S. Raslova, Hana Gilot, David Liu, Ziling Demengeot, Jocelyne Salbert, Gilles Douet-Guilbert, Nathalie Corcos, Laurent Galibert, Marie-Dominique Gandemer, Virginie Troadec, Marie-Bérengère ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis |
| title | ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis |
| title_full | ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis |
| title_fullStr | ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis |
| title_full_unstemmed | ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis |
| title_short | ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis |
| title_sort | etv6-runx1 and runx1 directly regulate rag1 expression: one more step in the understanding of childhood b-cell acute lymphoblastic leukemia leukemogenesis |
| topic | Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807389/ https://www.ncbi.nlm.nih.gov/pubmed/34535762 http://dx.doi.org/10.1038/s41375-021-01409-9 |
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