PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression

T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematologic disease caused by gene mutations in T-cell progenitors. As an important epigenetic regulator, PHF6 mutations frequently coexist with JAK3 mutations in T-ALL patients. However, the role(s) of PHF6 mutations in JAK3-driven leukemia...

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Detalles Bibliográficos
Autores principales: Yuan, Shengnan, Wang, Xiaomin, Hou, Shuaibing, Guo, Tengxiao, Lan, Yanjie, Yang, Shuang, Zhao, Fei, Gao, Juan, Wang, Yuxia, Chu, Yajing, Shi, Jun, Cheng, Tao, Yuan, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807395/
https://www.ncbi.nlm.nih.gov/pubmed/34465864
http://dx.doi.org/10.1038/s41375-021-01392-1

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