Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum

Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients...

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Autores principales: Urrea-Quezada, Alejandro, Balmaceda-Baca, Ruben, Garibay, Adriana, Hernández, Jesús, Valenzuela, Olivia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807513/
https://www.ncbi.nlm.nih.gov/pubmed/35127561
http://dx.doi.org/10.3389/fcimb.2021.810887
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author Urrea-Quezada, Alejandro
Balmaceda-Baca, Ruben
Garibay, Adriana
Hernández, Jesús
Valenzuela, Olivia
author_facet Urrea-Quezada, Alejandro
Balmaceda-Baca, Ruben
Garibay, Adriana
Hernández, Jesús
Valenzuela, Olivia
author_sort Urrea-Quezada, Alejandro
collection PubMed
description Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.
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spelling pubmed-88075132022-02-03 Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum Urrea-Quezada, Alejandro Balmaceda-Baca, Ruben Garibay, Adriana Hernández, Jesús Valenzuela, Olivia Front Cell Infect Microbiol Cellular and Infection Microbiology Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates. Frontiers Media S.A. 2022-01-19 /pmc/articles/PMC8807513/ /pubmed/35127561 http://dx.doi.org/10.3389/fcimb.2021.810887 Text en Copyright © 2022 Urrea-Quezada, Balmaceda-Baca, Garibay, Hernández and Valenzuela https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Urrea-Quezada, Alejandro
Balmaceda-Baca, Ruben
Garibay, Adriana
Hernández, Jesús
Valenzuela, Olivia
Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum
title Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum
title_full Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum
title_fullStr Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum
title_full_unstemmed Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum
title_short Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum
title_sort serum igg responses to gp15 and gp40 protein-derived synthetic peptides from cryptosporidium parvum
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807513/
https://www.ncbi.nlm.nih.gov/pubmed/35127561
http://dx.doi.org/10.3389/fcimb.2021.810887
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