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Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain

Nonribosomal peptide synthetases (NRPSs) are modular assembly-line megaenzymes that synthesize diverse metabolites with wide-ranging biological activities. The structural dynamics of synthetic elongation has remained unclear. Here, we present cryo-EM structures of PchE, an NRPS elongation module, in...

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Detalles Bibliográficos
Autores principales:	Wang, Jialiang, Li, Dandan, Chen, Lu, Cao, Wei, Kong, Liangliang, Zhang, Wei, Croll, Tristan, Deng, Zixin, Liang, Jingdan, Wang, Zhijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807600/ https://www.ncbi.nlm.nih.gov/pubmed/35105906 http://dx.doi.org/10.1038/s41467-022-28284-x

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