An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments

A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy. Transgenic mice overexpressing amyloid precursor protein (App) gene manifest non-physiological and ectopic expression of APP and its frag...

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Detalles Bibliográficos
Autores principales: Pang, Keliang, Jiang, Richeng, Zhang, Wei, Yang, Zhengyi, Li, Lin-Lin, Shimozawa, Makoto, Tambaro, Simone, Mayer, Johanna, Zhang, Baogui, Li, Man, Wang, Jiesi, Liu, Hang, Yang, Ailing, Chen, Xi, Liu, Jiazheng, Winblad, Bengt, Han, Hua, Jiang, Tianzi, Wang, Weiwen, Nilsson, Per, Guo, Wei, Lu, Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807612/
https://www.ncbi.nlm.nih.gov/pubmed/34789895
http://dx.doi.org/10.1038/s41422-021-00582-x

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